Hulya Savas MUTLUB, Emre GUNBEYA, Esra KAVAZA, Bilge Can MEYDANB, Recep UNALA, Hediye Pinar GUNBEYC

8431

Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis

Respiratory Epithelial Adenomatoid Hamartoma (REAH) is a type of hamartoma characterized by prominent glandular proliferations lined with ciliated respiratory epithelium originating from the surface epithelium. REAH should be differentiated from inflammatory nasal polyp, inverted papilloma and adenocarcinoma to avoid from more aggressive surgery then is needed for the REAH and to avoid from unnecessary long-term follow-up with medical treatments. In this report, we present a case of REAH who was followed up with topical and systemic steroids for years with the misdiagnosis of inflamatory nasal polyposis and discuss the clinical, radiological and histopathological features of the disease at increasing importance in recent years.  © 
Keywords:

Hamartoma, Nasal polyp, Olfactory cleft, Paranasal computed tomography, Respiratory epithelial adenomatoid,

PDF

___

  • Braun, J.J., Riehm, S., Averous, G., Billing, A., Veillon, F., 2013. MRI in respiratory epithelial adenomatoid hamartoma of nasal cavities. J. Neuroradiol. 40, 216-219. doi: 10.1016/j.neurad.2012.04.002.
  • Cao, Z., Gu, Z., Yang, J., Jin, M., 2010. Respiratory epithelial adenomatoid hamartoma of bilateral olfactory clefts associated with nasal polyposis: Three cases report and literature review. Auris Nasus Larynx. 37, 352-356. doi: 10.1016/j.anl.2009.10.003.
  • Fitzhugh, V.A., Mirani, N., 2008. Respiratory epithelial adenomatoid hamartoma: A review. Head Neck Pathol. 2, 203-220. doi: 10.1007/s12105-008-0064-3.
  • Gauchotte, G., Marie, B., Gallet, P., Nguyen, D.T., Grandhaye, M., Jankowski, R., Vignaud, J.M., 2013. Respiratory epithelial adenomatoid hamartoma: A poorly recognized entity with mast cell recruitment and frequently associated with nasal polyposis. Am. J. Surg. Pathol. 37, 1678-1685. doi: 10.1097/PAS.0000000000000092.
  • Hawley, K.A., Ahmed, M., Sindwani, R., 2013. CT findings of sinonasal respiratory epithelial adenomatoid hamartoma: A closer look at the olfactory clefts. Am. J. Neuroradiol. 34, 1086-1090.
  • Himi, Y., Yoshizaki, T., Sato, K., Furukawa, M., 2002. Respiratory epithelial adenomatoid hamartoma of the maxillary sinus. J. Laryngol. Otol. 116, 317-318.
  • Hua, X., Huang, X., Liao, Z., Xian, Q., Yu, L., 2014. Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma. Diagn. Pathol. 25, 9:70. doi: 10.1186/1746-1596-9-70.
  • Ingram, W.F., Noone, M.C., Gillespie, M.B., 2006. Respiratory epithelial adenomatoid hamartoma: A case report. Ear Nose Throat. J. 85, 190-192.
  • Lee, J.T., Garg, R, Brunworth, J., Keschner, D.B., Thompson, L.D., 2013. Sinonasal respiratory epithelial adenomatoid hamartomas: Series of 51 cases and literature review. Am. J. Rhinol. Allergy. 27, 322-328. doi: 10.2500/ajra.2013.27.3905.
  • Liang, J., O’Malley, B.W.Jr., Feldman, M., Newman, J.G., 2007. A case of respiratory epithelial adenomatoid hamartoma. Am. J. Otolaryngol. 28, 277-279.
  • Lorentz, C., Marie, B., Vignaud, J.M., Jankowski, R., 2012. Respiratory epithelial adenomatoid hamartomas of the olfactory clefts Eur. Arch. Otorhinolaryngol. 269, 847-852. doi: 10.1007/s00405-011-1713-9.
  • Metselaar, R.M., Stel, H.V., van der Baan, S., 2005. Respiratory epithelial adenomatoid in the nasopharynx. J. Laryngol. Otol. 119, 476-478.
  • Mühlmeier, G., Hausch, R., Arndt, A., Kraft, K., Danz, B., Maier, H., 2014. Respiratory epithelial adenomatoid hamartoma of the nose and nasal sinuses: A rare differential diagnosis of nasal polyposis. HNO. 62, 813-817. doi: 10.1007/s00106-014-2914-5.
  • Nguyen, D.T., Nguyen-Thi, P.L., Gauchotte, G., Arous, F., Vignaud, J.M., Jankowski, R., 2014. Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis. Laryngoscope. 124, 2461-2465. doi: 10.1002/ lary.24778.
  • Ozolek, J.A., Barnes, E.L., Hunt, J.L., 2007. Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: An immunohistochemical study. Arch. Pathol. Lab. Med. 131, 530-537.
  • Roffman, E., Baredes, S., Mirani, N., 2006. Respiratory epithelial adenomatoid hamartomas and chondroosseous respiratory epithelial hamartomas of the sinonasal tract: A case series and literature review. Am. J. Rhinol. 20, 586-590.
  • Vira, D., Bhuta, S., Wang, M.B., 2011. Respiratory epithelial adenomatoid hamartomas. Laryngoscope. 121, 2706-2709.
  • Wenig, B.M., Heffner, D.K., 1995. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: A clinicopathologic study of 31 cases. Ann. Otol. Rhinol. Laryngol. 104, 639-645.
Journal of Experimental and Clinical Medicine-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1980
  • Yayıncı: Ondokuz mayıs Üniversitesi Tıp Fakültesi
Arşiv
Sayıdaki Diğer Makaleler

Ahmet BEKTASD, Sude Hatun AKTİMURA, Piltan BUYUKKAYAA, Nevin Alayvaz ASLANA, Serdar TURANB, Hilmi ATAYA, Seda GÜNC, Engin KELKİTLİA, Mehmet TURGUTA

Hulya Savas MUTLUB, Emre GUNBEYA, Esra KAVAZA, Bilge Can MEYDANB, Recep UNALA, Hediye Pinar GUNBEYC

Gokay NARA, Gokhan AKSANB, Ozkan GORGULUC, Sinan INCİD, Korhan SOYLUE, Metin OZDEMİRF, Rukiye NARG, Serkan YUKSELE, Mahmut SAHİNE

Ismail KUCUKERA, Onur CUKURLUOGLUB, Tolga ERYİLMAZC, Serhan TUNCERD, Selahattin OZMENE

Veysel KARSA, Tahsin CELEPKOLUA, Ahmet YİLMAZA, Fatih ESMERB, Sevdegul KARADASC

Mahdi MARZİC, Tulin Guven GOKMENA, Fatih KOKSALC, Beril AKCİMENB, Begum KAYARC

Mehmet Ziya YİLMAZ, Aysun Caglar TORUN

Mehmet YAMANA, Musa SAHİNB, Hasan Ali GUMRUKCUOGLUB, Yilmaz GUNESC, Serkan AKDAGB, Mustafa TUNCERB

Ayse Zehra OZDEMİRA, Hasan ULUBASOGLUB, Davut GUVENA

Ahmet GOKYARA, Cengiz COKLUKB, Abdullah MARANGOZB