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Tiroit kanseri genetiği

iroit kanseri son yıllarda sıklığı giderek artış gösteren malignensilerden biridir. Moleküler mekanizmasının anlaşılmasındaki ilerlemeler, hastalığın önlenmesi, erken tanısı ve tedavisinde yarar sağlamaktadır. Somatik mutasyonlar ve diğer moleküler değişiklikler, tiroit kanseri tanısı için yararlı prognostik belirteçler olarak kabul edilmiş ve klinik uygulamaya da girmeye başlamıştır. Bu derlemede tiroit kanserinin genetik temeli anlatılmıştır. Tiroit kanserinde yaygın bulunan BRAF ve RAS gen mutasyonlarının yanı sıra RET/PTC ve PAX8/PPARγ kromozomal yeniden düzenlenmeleri de açıklanmıştır. Ayrıca gen ekspresyon profili, microRNA, epigenetik, genom çaplı ilişki çalışmaları, tek nükleotid polimorfizmi (SNP) analizleri ve tiroit karsinogenezinde ilişkili diğer genler açıklanmıştır.

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Journal of Experimental and Clinical Medicine-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1980
  • Yayıncı: Ondokuz mayıs Üniversitesi Tıp Fakültesi