INTRODUCTION   Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle components into the bloodstream.   CASE REPORT   A 29-year-old male patient presented to the emergency department complaining of nausea, vomiting and widespread body pain. Physical examination of the agitated patient who did not want to talk was as followed; Vitals: BP: 115/50, Pulse: 85, Sa02: 95. The patient was conscious, oriented, cooperative and his GCS was 15. Biochemical values ​​in laboratory tests; AST: 224, ALT: 183, LDH: 1273, CK: 33639, and drawn arterial blood gas were determined as follows: pH: 7.45, hHCO3:18.7, lactate: 2.4. All other laboratory tests were normal. An ECG was performed and it showed sinus tachycardia. When anamnesis was deepened, he stated that he used Sildenafil and alcohol 24 hours before and just 3 hours before his admission to the hospital. Patient informed us that there was no coitus. In the follow-up, the patient who was given hydration and sodium bicarbonate treatment did not develop dialysis necessity, his biochemical values ​​showed a rapid decrease of CK level 24000-11000-5000 and the patient was discharged because of the decline of all  his complaints. DISCUSSION Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle components into the bloodstream. The true incidence of Sildenafil-related renal matters is unknown, since the post-marketing data are very limited. More cases can be detected as the number of prescription of Sildenafil increases.    CONCLUSİON Even in patients with nonspecific symptoms, anamnesis (drug use, etc.) should be deepened. Physician awareness is important to prevent possible toxicities and systemic dysfunctions that may be caused by them.