Neriman ÇETİN BENLİ, Sibel MUTLU, Abdülkerim YILDIZ, Ali Ramazan BENLİ

Yüksek ortalama trombosit hacmi oligohidramnios ve polihidramnios için ek bir prediktif belirteç midir?

Amaç: Amniyotik sıvı anomalileri, fetal morbidite ve mortalitenin önde gelen nedenleridir. Bu çalışmanın amacı, prepartum ortalama trombosit hacminin (MPV), oligohidramnios (OHA) ve polihidramnios (PHA) ile ilişkisini inceleyerek prediktif bir marker olup olmadığını araştırmaktır.Gereç ve Yöntem: Bu retrospektif çalışmada, 2014-2015 yılları arasında Karabük Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniği'nde izlenen ve doğum yapan hastaların kayıtları incelenmiştir. İzole OHA ve PHA'lı hastalar çalışma grubuna, normal amniyon sıvısı hacmine (AFV) sahip hastalar ise kontrol grubuna dahil edildi. Gebeliğin üçüncü trimesterinde yaş, obstetrik ve klinik öykü, sigara kullanımı, alkol tüketimi, laboratuvar test sonuçları ve ultrasonografi rapor sonuçları kaydedildi.Bulgular: Çalışmaya toplam 284 gebe dahil edildi. OHA ve PHA gruplarının MPV seviyeleri kontrol grubuna göre anlamlı derecede yüksekti (p<0.05). OHA ve PHA grupları arasındaistatistiksel olarak anlamlı fark görülmedi (p>0.05). MPV> 8.4, AFV'yi doğru bir şekilde farklılaştırdı (AUC:% 68.8, duyarlılık:% 78.6, özgüllük:% 59.1). MPV> 8.0, OHA'yı doğru şekilde farklılaştırdı (AUC:% 67.1, duyarlılık:% 84.4, özgüllük:% 50.0). MPV> 8.5, PHA'yı doğru bir şekilde farklılaştırdı (AUC:% 70.2, duyarlılık:% 79.0, özgüllük:% 61.4). Tartışma: Bu çalışmanın sonuçları; MPV taramasının komplikasyon veya fetal anomali olmayan gebeliklerde OHA ve PHA için prediktif bir değere sahip olduğunu göstermektedir.

Anahtar Kelimeler:

Ortalama trombosit hacmi, Oligohidramnios, Polihidramnios, Amniyotik sıvı

Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios?

Objectives: Amniotic fluid abnormalities are the leading cause of fetal morbidity and mortality. The aim of this study was to investigate whether prepartum mean platelet volume (MPV) is associated with and a predictable marker for oligohydramnios (OHA) and polyhydramnios (PHA). Materials and Methods: In this retrospective study, an examination was made of the records of patients who were monitored and gave birth at Karabuk Training and Research Hospital Gynecology and Obstetrics Clinic in 2014-2015. Patients with isolated OHA and PHA were included in the study group and those with normal amnion fluid volume (AFV) in the control group. A record was made of age, obstetric and clinical history, smoking, alcohol consumption, laboratory test results and ultrasonography reports in the third trimester of the pregnancy.Results: A total of 284 pregnant women were included in the study. The MPV levels of the OHA and PHA groups were significantly higher than those of the normal group (p=0.000). There was no significant difference was observed between the OHA and PHA groups (p=0.20). MPV>8.4 accurately differentiated AFV (AUC:68.8%, sensitivity:78.6%, specificity:59.1%). MPV>8.0 accurately differentiated OHA (AUC:67.1%, sensitivity:84.4%, specificity:50.0%). MPV>8.5 accurately differentiated PHA (AUC:70.2%, sensitivity:79.0%, specificity:61.4%). Conclusion: The result of the current study shows that screening MPV has a predictive value for OHA and PHA in pregnancies without complications or fetal anomaly.

Keywords:

Mean Platelet Volume, Oligohydramnios, Polyhydramnios, Amniotic Fluid,

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