Türkiye'nin Akdeniz bölgesindeki Malign Mezotelyoma hastalarının klinikopatolojik özelliklerinin prognostik değeri

Amaç: Malign mezoteliyomalı (MM) hastaların klinikopatolojik özelliklerinin genel sağkalıma etkisini tanımlamak. Gereç ve Yöntemler: 2008-2020 yılları arasında medikal onkoloji kliniklerinde tedavi gören MM tanılı 41 hasta değerlendirildi. Hastaların klinikopatolojik özellikleri ve genel sağkalımı (OS) ve tedavi yöntemleri analiz edildi. Bulgular: Bu çalışmaya 41 hasta dahil edildi. Hastaların ortanca yaşı 63,5 idi. 16.7 (aralık:0.5-172.6) aylık medyan takipte hastaların %78'i (32) hayatını kaybetti. Medyan genel sağkalım 17.6 aydı. Tanı konulduğunda hastaların %65,9'u (27) evre 3 ve %29,3'ü (12) evre 4 hastalığı vardı. Hastaların çoğuna ileri evrede (Evre 3-4) (%95.2) tanı konuldu. Epiteloid histopatolojik alt tip tanısı alan hastaların medyan genel sağkalımı 32.4 ay, sarkomatoid olanların medyan genel sağkalımı 5.23 ay, bifaziklerin medyan genel sağkalımı 4.33 ay idi. Bu fark istatistiksel olarak anlamlıydı (p

Anahtar Kelimeler:

Malign mesotelioma, genel sağkalım, asbestos

Prognostic value of clinicopathological characteristic of patients with Malign Mesothelioma at Mediternean region of Turkey

Aim: To define the effect of clinicopathological characteristics of patients with malign mesothelioma (MM) on overall survival. Materials and Methods: Forty-one patients diagnosed with MM who were treated at the medical oncology clinics between 2008 to 2020 were assessed. Clinicopathological characteristics and overall survival (OS) of patients, and treatment modalities analyzed. Results: Forty-one patients were included in this study. The median age of patients was 63.5. At a median follow-up of 16.7 (range:0.5-172.6) months, 78%(32) of patients died. Median OS was 17.6 months. 65.9% (27) of patients had stage 3 and 29.3% (12) had stage 4 diseases when they were diagnosed. Most of the patients were diagnosed at the advanced stage (Stages 3-4) (95.2%). The median OS of patients diagnosed with epithelioid histopathologic subtype was 32.4 months, while the median OS of those with sarcomatoid was 5.23 months, while the median OS of biphasic was 4.33 months. This difference was statistically significant (p

Keywords:

malign mesothelioma, overall survival, asbestos,

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