Obsesif Kompulsif Bozuklukta B12 Vitamini, Folik Asit, Ferritin ve D Vitamini Düzeylerinin Değerlendirilmesi

Amaç: Obsesif kompulsif bozukluk (OKB), obsesyon ve kompulsiyonlarla karakterize heterojen bir bozukluktur. Yapılan çalışmalara rağmen etyopatogenezi tam olarak anlaşılamamıştır. OKB'de farmakolojik ve psikososyal müdahaleler, sınırlı etyopatogenez bilgisi nedeniyle yetersiz olabilir. Bu nedenle etiyopatogenez ile ilgili ucuz ve kolay saptanabilen biyokimyasal parametrelerin bulunması önemlidir. Bu çalışmada OKB ile B12 vitamini (VitB12), folik asit (FA), D vitamini (VitD) ve ferritin ilişkisi araştırıldı. Gereç ve Yöntem: Bu retrospektif çalışmaya 50 OKB hastası (12 kadın, 38 erkek) ve 50 sağlıklı kontrol (SK) (13 kadın, 37 erkek) dahil edildi. Her iki grubun serum VitB12, FA, ferritin ve 25-OH VitD düzeyleri karşılaştırıldı. Bulgular: VitB12 (p <0.001), FA (p =0.004) ve VitD (p =0.001) serum düzeyleri OKB grubunda HC grubuna göre anlamlı olarak düşüktü. Ferritin değerleri açısından iki grup arasında anlamlı fark yoktu. Sonuç: Çalışmamız OKB hastalarında serum VitB12, FA ve VitD eksikliğinin etyopatogenez ile ilişkili olabileceğini göstermektedir. Bu çalışma, etiyopatogenez ile ilgili yeni araştırmalara öncülük edebilir. Bunun için tedavi sonrası dönemi de içeren geniş katılımlı prospektif çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Obsesyon, B12 vitamini, folik asit, ferritin ve D vitamini

Anahtar Kelimeler:

Obsesyon, B12 vitamini, folik asit, ferritin ve D vitamini

Evaluation of Vitamin B12, Folic Acid, Ferritin and Vitamin D Levels in Obsessive Compulsive Disorder

Aims: Obsessive compulsive disorder (OCD) is a heterogeneous disorder characterized by obsessions and compulsions. Despite the studies, etiopathogenesis is not fully understood. Pharmacological and psychosocial interventions in OCD may be insufficient due to limited knowledge of etiopathogenesis. Therefore, it is important to find inexpensive and easily determined biochemical parameters related to etiopathogenesis. In this study, the relationship between OCD and vitamin B12 (VitB12), folic acid (FA), vitamin D (VitD) and ferritin was investigated. Material and Method: 50 patients with OCD (12 female, 38 male) and 50 healthy controls (HC) (13 female, 37 male) were included in this retrospective study. Serum VitB12, FA, ferritin and 25-OH VitD levels of both groups were compared. Results: VitB12 (p <0.001), FA (p =0.004) and 25-(OH)VitD (p =0.001) serum levels were significantly lower in the OCD group than in the HC group. There was no significant difference between the two groups in terms of ferritin values. Conclusion: Our study shows that serum VitB12, FA and VitD deficiency can contribute to etiopathogenesis in OCD patients. This study may lead to research to find new pathways related to etiopathogenesis. For this, prospective studies with large participation are needed, including the post-treatment period.

Keywords:

Obsession, vitamin B12, folic acid, ferritin and vitamin D.,

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