Beta Talasemi Taşıyıcılarında Platekrit, Ortalama Trombosit Volümü ve Trombosit Sayısı Arasındaki İlişki

Giriş: β-talasemi taşıyıcılığı genellikle asemptomatiktir, bununlaberaber beta globin zincirinde kalıtsal azalmadan dolayı hafifhipokromik mikrositer anemi gelişebilmektedir. Literatürde, talasemitaşıyıcılarında trombosit parametrelerini değerlendiren az sayıdaçalışma bulunmaktadır. Bu çalışmada amacımız talasemi taşıyıcılarındatrombosit parametrelerini değerlendirmektir. Ayrıca çalışmamızdaanemili ve anemisiz talasemi taşıyıcılarında platelet parametrelerinideğerlendirdik.Gereç ve Yöntem: Kesitsel çalışmamızda Gaziantep Üniversitesi TıpFakültesi ayaktan hasta polikliniklerine başvuran 1-16 yaş arası 153talasemi taşıyıcısı çocuk çalışmaya alındı.Bulgular: Doksan çocuğun trombosit sayıları normaldi. 59 (%38.5)çocukta trombositoz, dört (%2.6) çocukta trombositopeni saptandı.Hemoglobin seviyelerine göre iki gruba ayrıldı. Grup 1, hemoglobin<11g/dl (n=86), ve grup 2, hemoglobin≥11g/dl (n=67)’den oluşmaktaydı.Grup 1 olgularda trombosit sayısı ve platekrit, grup 2 olgularındananlamlı olarak yüksekti. (p<0.05) Logistik regresyon testinde trombositsayısı ve platekrit arasında lineer bir korelasyon görüldü (r=0.94,p<0.01), ancak trombosit sayısı ile yaş (r=-0.32, p<0.01), ortalamatrombosit volumü (r=-0.18, p<0.05), hemoglobin (r =-0.18, p<0.05)arasında negatif bir korelasyon görüldü.Sonuç: Talasemi taşıyıcılarında hem trombositoz hemdetrombositopeni olabileceğini bulduk. Ayrıca anemi gelişen talasemitaşıyıcılarında trombosit sayısı anlamlı olarak yüksekti.

Anahtar Kelimeler:

Talasemi, taşıyıcılık, çocuk, trombosit parametreleri

Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers

Aim: β-thalassemia carriers (BTC) is generally asymptomatic;however, in clinical practice, there is hypochromic microcytic mildanemia caused by a hereditary reduction in beta globin synthesis.In the literature, there is also some information about plateletindices in BTC. The aim of this study was to evaluate platelet indicesin children with BTC. In addition, we compared platelet indicesbetween anemia (Hb<11 g/dl) and non-anemia BTC (Hb ≥11 g/dl).Material and Method: A cross sectional study included a totalof 153 subjects aged 1-16 years were recruited from GaziantepUniversity Hospital outpatient clinics electronic database.Results: Platelet counts were normal in 90 patients with BTC.Thrombocytosis and thrombocytopenia were detected in 59(38.5%) and four (2.6%) patients, respectively. This study groupwas divided into two groups as group 1, cases<11 g/dl (n=86), andgroup 2, cases≥11g/dl (n=67) according to the hemoglobin levels.The children with the group 1 had significantly higher mean levelsof platelet counts and platecrit than those with group 2 (p<0.05).In the logistic regression test, linear correlation between plateletcounts and platecrit (r=0.94, p<0.01) was observed, whereas therewere inverse correlations between platelet counts and age (r=-0.32, p<0.01), mean platelet volume (r=-0.18, p<0.05), hemoglobin(r =-0.18, p<0.05).Conclusion: We found that both thrombocytosis andthrombocytopenia may occur in BTC. Herein we also foundsignificantly elevated platelet counts in BTC with anemia.

Keywords:

Thalassemia, carriers, child,

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