As a critical medicine, meaning in suffering plays a crucial role as terminal ill experience always accompanied several unwanted psychological and emotional sufferings. A worldwide phenomenon that in the early stages of terminal ill diagnosis cure becomes the primary concerned for both the patient and the family. However, in the face of medical helplessness psychological approach to terminal illness becomes essential to effectively deal with pain and non-pain symptoms. It is not a mere philosophical approach to terminal ill experience, but a humanistic approach that provides hope even in the face of inevitable death. The psychological approach to health and wellbeing becomes more essential as palliative end-of-life care aims to uplift the meaning making policy and purpose in suffering that contributed health to many. In fact, though there is no easy ways to deliver wellbeing of the whole and quality of life, but psychotherapeutic is an effective mechanism to deal with existential suffering, stress, loneliness, alienation, and discomfort usually inherit in the process of terminal ill experiences. The therapeutic aim is to minimize the existential issues that accompanied the terminal ill experience and act in the best benefit for the patient and family in clinical practices.