Benign Endometrial Polyp and Primary Endometrial Small Cell Neuroendocrine Carcinoma Confined to the Polyp: A Rare Association
Benign Endometrial Polyp and Primary Endometrial Small Cell Neuroendocrine Carcinoma Confined to the Polyp: A Rare Association
Neuroendocrine tumors (NETs) are a heterogeneous group of tumoral lesions originating from diffuse endocrine system cells. They occur mostly in the gastrointestinal system and the lung. Primary NETs of the female reproductive tract are rare. In a widely used classification, primary small cell neuroendocrine carcinomas (SCNECs) and large cell neuroendocrine carcinomas (LCNECs) of the endometrium were included in a subgroup of poorly differentiated neuroendocrine carcinomas. SCNECs of the endometrium are very rare and they are often combined with other epithelial neoplasms. Their myometrial and extrauterine invasions are common during the initial diagnosis due to their aggressive behaviors. In this article, we present a rare case of primary endometrial SCNEC detected within the benign endometrial polyp and without invasion of myometrium and extrauterine tissues in a 70-year-old female patient presenting with postmenopausal bleeding. Histopathologically, the tumor cells showed positive staining with Synaptophysin, the Ki-67 labeling index was 80-90%, the mitotic index was 15/10 per HPF and there was no necrosis and lymphovascular invasion. J Clin Exp Invest 2016; 7 (1): 106-109
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- 1. Taal BG, Visser O. Epidemiology of neuroendocrine tumours. Neuroendocrinology 2004;80:3-7.
- 2. Chun YK. Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review. J Pathol Translational Med 2015;49:450-461
- 3. Travis WD, Linnoila RI, Tsokos MG, et al. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma: an ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol 1991;15:529-553.
- 4. Huntsman DG, Clement PB, Gilks CB, Scully RE. Small-cell carcinoma of the endometrium: a clinicopathological study of sixteen cases. Am J Surg Pathol 1994;18:364-375.
- 5. Koo YJ, Kim DY, Kim KR, et al. Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases. Taiwan J Obstet Gynecol 2014;53:355-359.
- 6. Mulvany NJ, Allen DG. Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. Int J Gynecol Pathol 2008;27:49-57.
- 7. Toptas T, Tasova-Yildirim G, Karaveli S, Simsek T. Malignant mixed Mullerian tumor with small cell neuroendocrine differentiation: a case report and review of the literature. Eur J Gynaecol Oncol 2014;35:180-184.
- 8. Posligua L, Malpica A, Liu J, et all. Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread. Arch Pathol Lab Med 2008;132:1821-1824.
- 9. Albores-Saavedra J, Martinez-Benitez B, & Luevano E. Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. Intl J Gynecol Pathol 2008;27:333-339.
- 10. Altrabulsi B, Malpica A, Deavers MT, et all. Undifferentiated carcinoma of the endometrium. Am J Surg Pathol 2005;29:1316-1321.