Some authors have suggested possible loss of antioxidant levels in alcoholic subjects. Acamprosate may have 2+ modulator effect on antioxidant levels in the alcoholic subject due to its effects on Ca regulation. We inves- tigated effects of acamprosate on serum lipid peroxidation and antioxidant vitamin concentrations in alcoholic patients. Twelve male health control and twelve alcoholic patients were used in the study. After taken blood samples the patients received orally acamprosate for 3 weeks and blood samples were taken the patients again. Lipid peroxidation (LP) levels were higher in the alcohol group than in control although vitamin A, vitamin E and b-carotene values were lower in the alcohol group than in control. LP levels were decreased in treatment group compared with the alcohol group. Vitamin A and b-carotene in the treatment group were increased compared with the alcohol group. Serum vitamin C concentrations were not found to be statistically different in any of the groups. Oxidative stress has been proposed to explain the biological side effects of alcohol intake. Acamprosate modulated alcohol-induced oxidative stress and antioxidant vitamin levels in the alcoholic patients.