Ahmet Cihat GENÇ, İlhan HACIBEKİROĞLU

Mikrobiyota ve Kanser

Kanser, önemli bir halk sağlığı sorunudur. Günümüzde, onkoloji alanındaki çok önemli gelişmelere rağmen halen kanser küratif hastalıklar kategorisinde değildir. Ancak, kompleks karsinogenez aşamalarında rol oynayan faktörlerin saptanması ile bu yolda önemli adımlar atılmaktadır. İnsan Mikrobiyota projesi kapsamında son dönemde elde edilen veriler, vücudumuzun epitelyal yüzeylerinde yaşayan kommensal mikroorganizma türlerinin bu süreçte aktif rol aldığını, aynı zamanda kanser tedavisine verilen kişisel yanıtlar ve toksisite ile de ilişkili olduğunu göstermiştir. Sonuç olarak, kanser oluşumu ve tedavisi aşamalarında anahtar role sahip major bir faktörün daha ortaya çıkarılması, kansere bağlı kişisel, toplumsal ve ekonomik kayıpları azaltacaktır. Biz, bu derlemede, yakın zamanda yapılan çalışmalardan elde edilen verilere dayanılarak, Mikrobiyotanın, karsinogenezdeki rolünü ve kanser tedavilerine yanıt ve toksisite üzerine etkilerini değerlendirmeyi amaçladık.

Anahtar Kelimeler:

Kanser, Karsinogenes, Mikrobiyota

Microbiota and Cancer

Cancer is a major public health problem. Today, despite the very important developments in oncology, cancer is still not in the category of curative diseases. However, signifi cant steps are being taken in this direction by the identifi cation of factors that play a role in the stages of complex carcinogenesis. Recent data from the human microbiology project have shown that commensal microorganism species living on the epithelial surfaces of the body play an active role in this process and are also associated with personal responses to cancer treatment and toxicity. As a result, further exposure of a major factor with key roles in cancer development and treatment stages will reduce personal, social and economic losses associated with cancer. We aimed to assess the role of microbiota in carcinogenesis and their effects on response to cancer treatments and toxicity, based on the data obtained from recent studies in this review.

Keywords:

Cancer, Carcinogenesis, Microbiota,

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