Ayşe Zülal TOKAÇ, Tuğde Buse UĞUR, Buse Ecem KURUGÖL, Sevilay ALİGÜLÜ, Osman HAYRAN

COVID-19 Dönemindeki Kısmi Kapanmaların Tip 2 Diyabet Hastalarının Metabolik Kontrolü Üzerine Etkisi

Amaç: Bu araştırmada, COVID-19 dönemindeki kısmı kapanma uygulamalarının Tip 2 Diyabet Mellitus hastalarının metabolik kontrolü üzerine etkisinin incelenmesi amaçlanmıştır. Yöntem: Kesitsel tipte (Ekolojik trend araştırması) yapılan bu araştırma 20 Eylül 2019 ve 20 Eylül 2020 tarihleri arasındaki hasta kayıtlarına dayalı olarak yürütülmüştür. Metabolik kontrol parametrelerindeki değişim, kapanma öncesi ve sonrası dönemdeki Hemoglobin A1c (HbA1c), açlık plazma glikoz (FPG), Kreatinin (Cr), açlık trigliserit (FTG) ve düşük yoğunluklu kolesterol (LDL-C) değerlerinin arasındaki farklılık incelenerek tespit edilmiştir. Yaş (65 yaş üzerine uygulanan kısmi kapanma önlemleri nedeniyle) ve cinsiyete bağlı alt grup analizleri de yapılmıştır. Bulgular: Kapanma öncesine döneme kıyasla açlık plazma glikoz ve trigliserit seviyelerinde kapanma sonrası dönemde istatistiksel olarak önemli artış tespit edilmiştir (sırasıyla, p=0.036 and p=0.013). Ancak HbA1c, LDL-C, kolesterol ve kreatinin seviyelerinde farklılık bulunamamıştır. Alt grup analizlerinde, <65 yaş ve erkek grupta açlık plazma glikoz ve trigliserit seviyelerindeki artış devam ederken, ≥65 yaş ve kadın grupta hiçbir değerde değişiklik tespit edilememiştir. Sonuç: Çalışmamıza göre, COVID-19 dönemindeki kısmi kapanma dönemi T2DM hastalarının metabolik kontrol parametrelerini olumsuz etkilemiştir. Bununla birlikte, açlık plazma glukoz seviyelerindeki artışa rağmen HbA1c değerlerinde bir değişme tespit edilememiştir. Parametrelerdeki kötüleşme, muhtemelen kısmi kapanma önlemlerinden daha fazla etkilenmeleri nedeniyle erkek ve <65 yaş grubunda, kadın ve ≥65 yaş grubuna kıyasla, daha belirgin olarak ortaya çıkmıştır.

Anahtar Kelimeler:

diyabetes mellitus, metabolik kontrol, kısmi kapanma, tip 2 diyabetes mellitus, COVID-19

The Impact of Partial Lockdown During COVID-19 Pandemic on Metabolic Control in People with Type 2 Diabetes Mellitus

Objective: In this study, it was aimed to determine the effects of lockdown due to COVID-19 on the metabolic control in people with type 2 diabetes mellitus. Methods: This cross-sectional study (Ecological trend study) was conducted based on the medical records of patients with type 2 diabetes between September 20, 2019 and September 20, 2020. The metabolic control changes were evaluated as differences of haemoglobin A1c (HbA1c), fasting plasma glucose (FPG), creatinine (Cr), fasting triglyceride (FTG) and low-density lipoprotein-cholesterol (LDL-C) values during pre-lockdown and lockdown periods. The stratified analysis based on age (due to partial closure measures applied over the age of 65) and gender was also performed. Results: There are statistically significant increases between FPG levels and FTG levels in the “during lockdown” group compared to the “pre-lockdown” group (p=0.036 and p=0.013 respectively) while the differences between HbA1c, LDL, cholesterol and creatinine levels are not significant. In subgroup analysis, increases in FPG and FTG levels remained in both <65 years and male groups, but no significant difference in any parameter was found in both ≥65 years and female groups. Conclusion: COVID-19 partial lockdown period negatively impacts metabolic control in people with T2DM according to our study results. Although FPG significantly increased, this increase was not found in HbA1c levels. The worsening was more pronounced in the males and patients <65 years than in females and patients ≥ 65 years possibly because of major changes in lifestyle due to partial lockdown measures conducted in Turkey.

Keywords:

COVID-19 Diabetes Mellitus, Diabetes Mellitus, Type 2, Metabolic Control, Partial Lockdown,

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