The Role of Gender Regarding the Outcomes of Pulmonary Rehabilitation in Patients with COPD: A Retrospective Study

PURPOSE: Our aim is to compare the pulmonary rehabilitation outcomes of male and female patients diagnosed with COPD. METHODS: Outpatient PR program, consisting of 16 sessions, two times a week for two months was applied to the patients with COPD (41 males, 41 females). arterial blood gas (ABG) analyzes and pulmonary function tests (PFT), 6-minute walking test (6MWT), dyspnea scale (mMRC), health-related quality of life (QoL) questionnaire (SF-36), disease-specific health status (SGRQ) were applied to all participants before and after PR. RESULTS: There was no statistically significant differences between the two groups before PR in terms of age, BMI, PFT parameters, and ABG results. Cigarette consumption was higher in men(p=0.02). Quality of life survey results (SGRQ, SF36), HAD anxiety, mMRC were similar in both groups before PR(p>0.05 for all).After PR, both clinical and statistically significant improvements were detected in 6mWD in both groups (p

Keywords:

COPD, pulmonary rehabilitation gender, COPD, pulmonary rehabilitation, gender,

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References 1. Gold 2020 Report; Global Strategy for The Diagnosis, Management, And Prevention of COPD page:16, Rehabilitation, Education & Self-Management part page:57.
2. Han MK, Postma D, Mannino DM, et al. Gender and chronic obstructive pulmonary disease: why it matters. Am J Respir Crit Care Med 2007;176:1179-84.
3. Aryal S, Diaz-Guzman E, Mannino DM. COPD and Gender Differences: An Update. TranslRes 2013;162:208-18.
4. Chapman KR. Chronic obstructive pulmonary disease: are women more susceptible than men? Clin Chest Med 2004;25:331-41.
5. Dransfield MT, Washko GR, Foreman MG, et al. Gender differences in the severity of CT emphysema in COPD. Chest 2007;132:464-70.
6. Miller MR, Jordan RE, Adab P. Gender differences in COPD: are women more susceptible to smoking effects than men? Thorax 2011;66:921-2.
7. Nguyen LP, Beck E, Cayetano K, et al. Differential Pulmonary Rehabilitation Outcomes in Patients with and without COPD: Role of Gender. J Cardiopulm Rehabil Prev 2017;37:350-5.
8. Sahin H, Varol Y, Naz I, et al. Effectiveness of pulmonary rehabilitation in COPD patients receiving long-term oxygen therapy. Clin Respir J 2018;12:1439-46.
9. Varol Y, Şahin H, Aktürk Ü, et al. Effect of Pulmonary Rehabilitation on the Value of the Inspiratory Capacity-to-Total Lung Capacity (IC/TLC) Ratio to Determine Response to Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease. Turk Thorac J 2019;20:224-9.
10. Miller MR, Crapo R, Hankinson J, Burgos F, Casaburi R, Coates A, et al; ATS/ERS task force. General considerations for lung function testing. Eur Respir J 2005;26:153-161.
11. Sweer L and Zwillich CW. Dyspnea in the patient with chronic obstructive pulmonary disease. Etiology and management. Clin Chest Med 1990;11:417-45.
12. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166: 111-7.
13. Polatlı M, Yorgancıoglu A, Aydemir O, et al. Validity and reliability of Turkish version of St. George’s respiratory questionnaire. Tuberk Toraks 2013;61:8187.
14. Kocyigit H, Aydemir O, Fisek G, et al. Validity and reliability of Turkish version of Short Form SF-36. Turkish J Drugs Therapeutics 1999;12:102-6.
15. Enright PL, Sherrill, DL. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 1998;158:1384-7.
16. Halbert RJ, Natoli JL, Gano A, et al. Global burden of COPD: systematic review and meta-analysis. Eur Respir J 2006;28:523-52.
17. Cote CG, Chapman KR. Diagnosis and treatment considerations for women with COPD. Int J Clin Pract 2009;63:486-93.
18. de Torres JP, Casanova C, Hernandez C, et al. Gender associated differences in determinants of quality of life in patients with COPD: a case series study. Health Qual Life Outcomes 2006;4:72.
19. Lieberman L, Meana M, Stewart D. Cardiac rehabilitation: gen- der differences in factors influencing participation. J Womens Health 1998;7:717-23.
20. Paolucci S, Bragoni M, Coiro P, et al. Is sex a prognostic factor in stroke rehabilitation? Stroke 2006;37:2989-94.
21. Robles PG, Brooks D, Goldstein R, et al. Gender-Associated Differences in Pulmonary Rehabilitation Outcomes in People with Chronic Obstructive Pulmonary Disease. J Cardiopulm Rehabil Prev 2014;34:87-97.
22. Haggerty MC, Stockdale-Woolley R, ZuWallack R. Functional status in pulmonary rehabilitation participants. J Cardiopulm Rehabil Prev 1999;19:35-42.
23. Skumlien S, Skogedal EA, Bjortuft O, et al. Four weeks’ intensive rehabilitation generates significant health effects in COPD patients. Chron Respir Dis 2007;4:5-13.
24. Ninot G, Fortes M, Poulain M, et al. Gender difference in coping strategies among patients enrolled in an inpatient rehabilitation program. Heart Lung 2006;35:130-136.
25. DeMeo DL, Ramagopalan S, Kavati A, et al; COPD Gene Investigators. Women manifest more severe COPD symptoms across the life course. Int J Chron Obstruct Pulmon Dis 2018;13:3021-9.
26. Celli B, Vestbo J, Jenkins CR, et al. Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience. Am J Respir Crit Care Med 2011;183:317-22.
27. Özdemir T, Candemir I, Ergün P, et al . Patients with COPD who underwent pulmonary rehabilitation in Turkey: prevalence, distribution, and mortality. Turk J Med Sci 2020;50:141-7.