Oğuz ÇETİNAYAK, Barbaros AYDIN, İlhami ER, İlhan ÖZTOP, Nesrin AKTÜRK, Rıza ÇETİNGÖZ, Volkan KARACAM, Meltem KİRLİ, Ayşe Nur DEMİRAL

Long-Term Survival With Salvage Surgery in Persistent Lung Cancer

Objective: Our study presents a case with locally-advanced non-small cell lung cancer (NSCLC) having salvage pneumonectomy due topersistent disease.Case Description: A 46-year old man with stage IIIB (cT4N3M0) NSCLC received 39Gy (13x3Gy) thoracic radiotherapy after neoadjuvantchemotherapy. Partial response was obtained after radiotherapy. Chemotherapy was continued after radiotherapy. At 28th month of followup without treatment, isolated local progression was detected. The patient underwent right pneumonectomy and mediastinal lymph nodedissection revealing ypT2aN0 adenocarcinoma. After adjuvant chemotherapy, he’s disease-free at 88 months after salvage surgery.Conclusion: In selected patients, salvage surgery seems to provide increased survival causing acceptable morbidity and mortality.

PDF

___

1.Jeremic B, Videtic G. Chest reirradiation with external beam radiotherapy for locally recurrent non-small cell lung cancer: A review. Int J Rad Oncol Biol Phys 2011;80:969–977. [CrossRef]
2. Dickhoff C, Dahele M, Paul MA, et al. Salvage surgery for locoregional recurrence or persistent tumor after high dose chemoradiotherapy for locally-advanced non-small cell lung cancer. Lung Cancer 2016;94:108–113. [CrossRef]
3. Bauman JE, Mulligan MS, Martins RG, Kurland BF, Eaton KD, Wood DE. Salvage Lung Resection After Definitive Radiation (>59 Gy) for Non-Small Cell Lung Cancer: Surgical and Oncologic Outcomes. Ann Thorac Surg 2008;86:1632–1639. [CrossRef]
4. Yang CJ, Meyerhoff RR, Stephens SJ, et al. Long term outcomes of lobectomy for non-small cell lung cancer after definitive radiation treatment. Ann Thorac Surg 2015;99:1914–1920. [CrossRef]
5. Casiraghi M, Eng PM, Piperno G, et al. Salvage Surgery After Definitive Chemoradiotherapy for Non-small Cell Lung Cancer. Semin Thorac Cardiovasc Surg 2017;29:233–241. [CrossRef]
6. Uramoto H, Tanaka F. Salvage thoracic surgery in patients with primary lung cancer. Lung Cancer 2014;84:151–155 [CrossRef] .