Sevecen Seyhun NASİR, Aysegül YURT, Nuri KARABAY, Cenk UMAY, Barbaros AYDİN, Ayse Nur DEMİRAL

Correlation Between CT-Simulator and Dynamic Magnetic Resonance Images in Determining The Location of Gross Tumor Volume in Radiotherapy Treatment Planning for Lung Cancer

Objective: This study aimed to determine the accuracy of the average tumor location in CT-simulator images and PTV margins in radiotherapy treatment planning by detecting lung tumor mobility in dynamic MRI scans of patients presenting with lung cancer.Materials and Method: Dynamic MRI examination was performed in 12 lung cancer patients scheduled for 3-dimensional conformal RT 3D-CRT using CT-simulator. In this study, maximum tumor displacement CC-MRI, ML-MRI, AP-MRI was measured that occurred in CC, AP and ML axes in expiratory and inspiratory phases of dynamic MRI. The distance from the upper limit of GTV to the reference line CC-CT was measured in CT-simulator images. CC-CT and CCmean-MRI values were compared with the Wilcoxon signed-rank test. Furthermore, correlation of these values was evaluated with Spearman’s correlation test.Results: In comparison of CC-CT and CCmean-MRI values, no statistically significant difference was detected between CT-simulator and dynamic MRI modalities p=0.172 . In addition, a high level of correlation was found between these two imaging methods p

Keywords:

lung cancer, respiratory motion, radiotherapy, dynamic magnetic resonance imaging, CT-simulator,

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