The twisting of the gravid uterus during pregnancy is more common in the Egyptian buffaloes than any other domestic species. Available f eld and hospital cases (n=36) were included in this study. The treatment procedure and the clinicopathological f ndings (before detorsion, after detorsion, immediately after birth and 24 hours after birth) of the buf faloes suffering from uterine torsion were investigated. The total number of successfully rolled buffaloes was signif cantly higher (P<0.05) than those failed to be rolled, and the severe torsion needed >2 rolls to be corrected. Caesarean section (C.S) was successfully completed in the majority of cases. The rate of maternal and foetal mortality increased with the severity of torsion. Most cases of torsion were accompanied with dilated cervix than insuff cient or closed cervix. The rate of bloody discharge (P<0.05) and ruptured foetal sacs increased with the severity of torsion reaching the highest with >270° torsion. Heparinized blood samples were collected to perform a complete blood picture, and plasma samples were used for analysis of some biochemical parameters and hormones. The results of haemogram in the affected buffaloes with uterine torsion showed normocytic normochromic anaemia and leucocytosis accompanied by neutrophilia and monocytosis. Biochemical analysis revealed signi f cant (P<0.01) changes in the plasma levels of AST, LDH, glucose, total protein, albumin, blood urea nitrogen (BUN) and creatinine in the af fected buffaloes than the control. Hormonal analysis showed signif cant (P<0.001) increase in progesterone and cortisol levels in association with a signi f cant (P<0.001) decrease in the level of estradiol-17ß in the af fected buffaloes with uterine torsion. The present study suggested that, there was a signi f cant change regarding the haemogram, biochemical constituents and hormonal pro f les, specially before and after detorsion and immediately after birth in Egyptian buffaloes with uterine torsion