Textile industry is one of the most important industries of Turkey. The exit water of textile industry, which involves textile dyes including variety of chemicals and complicated structure, harms the environment widely. Biological treatment methods has attracted the attentions not only because of its low investment and operating costs but also because of being a simple and environment friendly treatment process. White rot fungi are used as a biological system in degradation and decolorizing of textile dyes.In this study, the biological purification of dyes intended to lower the cost and as soon as possible. In this study, some of the reactive textile dyes (Blue 49, Orange 12, Orange 13, Red 31, Black 5, RBBR). Pleurotus sajor-caju has been optimized for parameters that affect the color removal. At different pH (3.5, 4.5, 5.5, and 6.5) dye concentration (25, 50 and 100 mg/l), shaking speed (100, 150 and 200 rpm) and temperature (25, 30, 35 and 40°C) investigated the effect of decolorization. Optimum conditions, the degradation of dyes percentages ranged from %70 and %93. The most resistant to degradation dye of the Orange 12 and Orange 13 was. Blue 49 and RBBR is the fastest degradable. pH 4.5 optimum conditions for decolorization of dye concentration of 50 mg/l, shaking speed of 200 rpm and a temperature of 30°C were determined