Murat GÜZEL, Ahmet KOÇ, Ramazan DURGUT, Ramazan GÖNENCİ, Sefa ÇELİK, Ramazan BAL, M. Enes ALTUĞ, E. Özlem ATEŞOĞLU

Effects of high dose lead toxication on liver, kidneyse, heart, brain and blood in rabbits: An experimental study

The aim of the study was to investigate effects of high dose lead (Pb) exposure on heart, blood, kidney, liver and brain in rabbits using clinical, electrocardiographical (ECG), ultrasonographical, haematological, biochemical and pathological methods. The experiments were performed on 15 male New Zealand rabbits, divided into three equal groups and were orally given 80 ppm or 160 ppm Pb for 15 days and the other group was used as control. Administration of 80 or 160 ppm lead signifi cantly increased the activities of serum aspartate aminotransferase (AST), alanin aminotransferase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and alkaline phosphatase (ALP). Hemoglobin (HB) and hematocrit (HCT) values were signifi cantly lower in 80 and 160 ppm Pb-treated animals compared to the control animals (p

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