PAROTİD GLANDIN PRİMER MERKEL HÜCRELİ KARSİNOMU

Merkel hücreli karsinom (MCC) cildin nadir ve agresif seyirli nöroendokrin tümörüdür. Bu tümör tükrük bezinde ise oldukça nadir görülür. MCC da lokal rekürrens, lenf nodu metastazı ve uzak metastaz sıktır. Biz burada parotid glandın primer Merkel hücreli karsinomunu sunduk.

Primary Merkel Cell Carcinoma Of The Parotid Gland

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin. This tumor is very rare in the salivary gland. Localrecurrence, lymph node metastasis, and distant metastasis are common in MCC. Here, we presented the primary Merkel cell carcinoma ofthe parotid gland

___

  • 1. Toker C. Trabecular carcinoma of the skin. Arch Dermatol. 1972;105:107–10
  • 2. Tang CK, Toker C. Trabecular carcinoma of the skin: an ultrastructural study. Cancer. 1978;42:2311–21.
  • 3. Saeb-Lima M. Montante-Montes de Oca D, Albores-Saavedra J. Merkel cell carcinoma with eccrine differentiation: a clinicopathologic study of 7 cases. Ann Diagn Pathol. 2008;12:410–4.
  • 4. Ghaderi M, Coury J, Oxenberg J, Spector H. Primary Merkel cell carcinoma of the parotid gland. Ear Nose Throat J 2010;89(7)
  • 5. Knopf Andreas, Bas Murat, Hofauer Benedikt, Mansour Naglaa, Stark Thomas. Clinicopathological characteristics of head and neck Merkel cell carcinomas. Head Neck 2016
  • 6. Agelli M, Clegg LX, Becker JC, et al. The etiology and epidemiology of Merkel cell carcinoma. Curr Probl Cancer. 2010;34:14–37.
  • 7. Gnepp DR, Corio RL, Brannon RB. Small cell carcinoma of the major salivary glands. Cancer. 1986;58:705–14.
  • 8. Feng H, Shuda M, Chang Y, et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096–100
  • 9. Gioacchini Federico Maria, Postacchini Valentina, Simonetti Oriana, Offidani Annamaria, Magliulo Giuseppe. Massimo Re: Merkel cell carcinoma : a systemic review of ENT presentation. Eur Arch Oto-Rhino-Laryngol 2013;270:2191–9
  • 10. Szeder V, Grim M, Halata Z, Sieber-Blum M. Neural crest origin of mammalian Merkel cells. Dev Biol 2003;253(2):258–63
  • 11. Fornelli A, Eusebi V, Pasquinelli G, Quattrone P, Rosai J. Merkel cell carcinoma of the parotid gland associated with Warthin tumour: report of two cases. Histopathology 2001;39(4):342–6.
  • 12. Chernock RD, Duncavage EJ, Gnepp DR. Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype. Am J Surg Pathol. 2011;35:1806–11.
  • 13. American Joint Committee on Cancer. AJCC cancer staging manual. eighth ed. Springer; 2017. Chapter 46.
  • 14. Basati M, Kassam K, Messiha A. Secondary Merkel cell carcinoma manifested in the parotid: case reports in dermatological medicine. 2013. p. 4.
  • 15. Hui KK, Luna MA, Batsakis JG, et al. Undifferentiated carcinomas of the major salivary glands. Oral Surg Oral Med Oral Pathol. 1990;69:76–83
  • 16. Jorcano S, Casado A, Berenguer J. Primary neuroendocrine small cell undifferentiated carcinoma of the parotid gland. Clin Transl Oncol. 2008;10:303–6