Recep Civan YÜKSEL, Mevlut BAŞKOL, Selda KORKMAZ, Murat AKSU

İrritabl Bağırsak Sendromunda Merkezi İletim Zamanı

Amaç: İrritabl bağırsak sendromunun (İBS) patofizyolojisi tam olarak anlaşılamamıştır. Bu nedenle, hastalık etkili bir tedaviden yoksundur. Somatosensoriyel uyarılmış potansiyel (SEP), somasensoriyel yoldaki bozuklukları tespit etmek için kullanılan elektro-nörofizyolojik bir ölçüm yöntemidir. Çalışmamızda İBS’de SEP ile somatosensoriyel bozukluk olup olmadığını araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmaya dahil edilme kriterlerine göre 13 İBS hastası ve 13 kontrol seçilmiş ve deneyimli bir nörolog tarafından tibial ve sural somatosensoriyel uyarılmış potansiyeller ölçülmüştür. Sonuçlar, hastalar hakkında bilgi sahibi olmayan deneyimli başka bir nörolog tarafından yorumlandı. Bulgular: Hasta grubunda 8 kişide (%61.5), kontrol grubunda 13 kişide (%11) SEP yanıtı ölçtük ve her iki grup arasında bu oranlar arasında istatistiksel olarak anlamlı fark vardı. Kontrol grubuna kıyasla IBS hastalarında Sural N27P32 ve Sural P32N50’nin tepe amplitüdlerinde istatistiksel olarak anlamlı bir artış gözlemledik. Gruplar arasında sural SEP latansı, tibial SEP latansı ve amplitüdleri açısından anlamlı fark yoktu. Sonuç: İBS hasta grubunda sağlıklı kontrol grubuna göre somatosensoriyel yolda bozulma görüldü. Bu bozukluk somatik bileşenden ziyade sensoriyal kompenenti içeriyordu. Bu, İBS hastalarında sensorial bileşendeki bozulmayı SEP yöntemiyle ortaya koyan ilk çalışmadır

Anahtar Kelimeler:

İrritabl barsak sendromu, somatosensoriyel uyarılmış potansiyeller, merkezi iletim zamanı

Central Transmission Time in Irritable Bowel Syndrome

Objective: Pathophysiology of irritable bowel syndrome (IBS) is not completely understood. Thus, the disease lacks an effective treatment. Somatosensory evoked potential (SEP) is an electroneurophysiological measurement method used to detect disorders in the somasensory pathway. In our study, we aimed to investigate whether there is a somatosensory disorder with SEP in IBS. Material and Methods: Thirteen IBS patients and 13 control case were selected according to inclusion criteria of the study and tibial and sural somatosensory evoked potentials were measured by an experienced neurologist. The results were interpreted by another experienced neurologist who was not informed about the cases. Results: We measured SEP response in 8 cases (%61. 5) in patient group and in 13 cases (%11) in the control group and there was a statistically significant difference between these ratios of both groups. We observed a statistically significant increase in peak to peak amplitudes of Sural N27P32 and Sural P32N50 in IBS patients compared to control group. There was no significant difference between groups in terms of sural SEP latency, tibial SEP latency and amplitudes. Conclusion: The somatosensory pathway was impaired in the IBS patient group compared to the healthy control group. This disorder included the sensory component rather than the somatic component.

Keywords:

Irritable bowel syndrome, somatosensory evoked potentials, central transmission time,

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