Cemalettin AYVAZOĞLU, Erhan GÖKÇE, Hidayet Metin ERDOĞAN

Şap hastalığından ölen bir buzağıda kardiyak belirteçlerdeki değişiklikler

Bu rapor Şap hastalığı olan bir buzağıda miyokardiyal dejenerasyon sırasında kardiyak troponin ekspresyonundaki değişiklikleri belirlemek için yapılmıştır. Sunulan olgu, Tarım ve Orman Bakanlığı Şap Enstitüsü tarafından Şap (O-tipi) tanısı konan annesi tarafından beslenen 7 günlük bir buzağı üzerinde gerçekleştirildi. Raporda kullanılan buzağı anneden emdiği kolostrum nedeniyle miyokarditis’e yakalanmıştır. Hastanın V. Jugularis’den alınan kan örneği ile serum cTn-T, cTn-I, CK-MB, LDH, AST ve ALT seviyeleri ticari kitler kullanılarak ölçüldü. cTn-T, cTn-I, CK-MB, LDH, AST ve ALT seviyeleri sırasıyla 1.00 ng/mL, 26.68 ng/mL, 262 U/L, 4503 U/L, 56.6 U/L, 55.3 U/L tespit edildi ve sağlıklı buzağılara göre bu değerler yüksek bulundu. Kardiyak troponinlerin (cTn-I, cTn-T) hastalığın tanısında kullanılmasının doğru ve hızlı sonuç vereceği düşünülmektedir.

Anahtar Kelimeler:

Buzağı, CK-MB, cTn-T, cTn-I, Şap Hastalığı

Changes in cardiac markers in a calf died of foot and mouth disease

This report disclosed changes in cardiac troponin expression during myocardial degeneration in a calf with foot and mouth disease (FMD). The case presented was a 7-day-old calf milk fed by its mother which diagnosed as having FMD (O-type) by Ministry of Agriculture and Forestry Şap (Foot and Mouth Disease) Institute. The calf suffered from myocarditis due to suckling FMD infected dam. Blood sample was taken from the jugular vein of calf. Serum cTn-T, cTn-I, CK-MB, LDH, AST and ALT levels were measured using commercial kits. cTn-T, cTn-I, CK-MB, LDH, AST and ALT levels were determined as 1.00 ng/mL, 26.68 ng/mL, 262 U/L, 4503 U/L, 56.6 U/L, 55.3 U/L, respectively and these values were higher than those of healthy calf. It is thought that the use of cardiac troponins (cTn-I, cTn-T) for the diagnosis of the disease will give accurate and rapid results.

Keywords:

Calf, CK-MB, cTn-I, cTn-T, FMD,

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