Nafiye YILMAZ, Ali İrfan GÜZEL, Yaprak ÜSTÜN ENGİN, Seda TOPÇU, Aslı OSKOVİ, Hasan Onur TOPÇU, Nedim ÇİÇEK

Polikistik over sendromunun adolesan ve erişkinlerde klinik ve laboratuar parametreler açısından karşılaştırılması

Amaç: Polikistik over sendromu PKOS kadınlarda anovulasyon, hirşutism ve infertilitenin en önemli nedenidir. Perimenarş döneminde başlayan ovulatuar disfonksiyon, hiperandrojenizm, hiperinsülinemi ve insülin resistansıyla ilişkilidir. Reprodüktif çağdaki kadınlarda prevelansı %3-23 arasında değişmektedir. Adolesanlarda PKOS tanısı için tanımlanmış kriterler mevcut değildir. National Institutes of Health ve Rotterdam kriterleri pratikte halen kullanılmaktadır. Biz çalışmamızda; Rotterdam kriterlerini tanı için kullandık ve polikistik over sendromu tanısı almış adolesan ve reprodüktif çağdaki kadınları klinik ve laboratuar parametreler açısından karşılaştırdık. Gereç ve Yöntemler: Çalışmamıza Rotterdam kriterlerine göre PKOS tanısı konulmuş 14-18 yaşları arasındaki adolesan kızlar ve 25-32 yaşları arasında reprodüktif çağdaki kadınlar dahil edildi. Vücut kitle endeksi VKI , bel-kalça oranı ve serum FSH, LH, E2, PRL, TSH, total testosteron, serbest testosteron, insülin, HOMA-IR düzeyleri her iki grupta hesaplandı. Bulgular: VKI, bel-kalça oranı, serum FSH, E2, PRL, TSH ve LH/FSH oranı her iki grupta benzer bulundu. Ancak serum LH, total testosteron, serbest testosteron, insülin, HOMA-IR değerleri gruplar arasında istatistiksel olarak farklı bulundu. Sonuç: Çalışmamızda, hiperandrojenizm ve insülin değerleri adolesan PKOS’larda erişkin çağdaki PKOS’lu kadınlara göre daha yüksek bulundu. Bize göre, bu bulgular ile pubertede meydana gelen metabolik değişiklikler arasında ilişki olabilir.

Anahtar Kelimeler:

Polikistik over sendromu, adolesan, hiperandrojenism

Comparison of the clinical and laboratory outcomes in adolescent and adults with polycystic ovary syndromeComparison of the clinical and laboratory outcomes in adolescent and adults with polycystic ovary syndrome

Background: Polycystic Ovary Syndrome PCOS is the leading cause of anovulation, hirsutism, and infertility in women of all ages. It is associated with ovulatory dysfunction beginning in the perimenarchal period, hyperandrogenism, hyperinsulinemia, and insulin resistance. For adult women the prevalence of PCOS ranges from 3% to 23%. There are no established diagnostic criteria for the diagnosis of PCOS in adolescents. Both the National Institutes of Health and the Rotterdam criteria are used in practice. We used Rotterdam criteria for the diagnosis. In current study, we compared the clinical and laboratory outcomes in adolescents and adults with PCOS.Materials and Methods: Females aged 10 to 18 years old for the adolescent group and aged 25 to 32 years old for the reproductive age group with a diagnosis of PCOS using the Rotterdam criteria enrolled in the study. Risk factors were recorded; BMI body mass index, Waist/hip, FSH, LH, E2, PRL, TSH, Total Testosterone, Free Testosterone, Insulin, HOMA IR.Results: There was no statistical significance between the groups in terms of BMI, waist/hip, FSH, E2, LH/FSH, PRL, TSH. However, LH, Total Testosterone, Free Testosterone, Insulin, HOMA-IR values were statistically significantly different between the groups.Conclusion: Our study showed that hyperandrogenism, and insulin values are seen higher in adolescent PCOS than adult PCOS. In our opinion, there may be a likely relationship between these findings and metabolic differences in puberty.

Keywords:

Polycystic Ovary Syndrome, Adolescent, Hyperandrogenism,

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