Histopatolojik Olarak Ektopik Gebe Olduğu Kanıtlanan Hastalarda Serum Ca-125, Östradiol ve Progesteron Düzeyleri
Amaç: Serum östradiol, progesteron, E2-P oranı ve kanser antijen 125 düzeylerinin normal gebelik ve ektopik gebeliği olan hastalarda karşılaştırılarak, bu parametrelerin ektopik gebeliğin erken tanısında muhtemel etkisinin belirlenmesi amaçlanmaktadır.Gereç ve Yöntemler: Çalışma grubuna; ektopik gebelik tanısı ile opere olup histopatolojik olarak tanısı doğrulanan 100 hasta dahil edildi. Kontrol grubunda ise 6-8 haftalar arasında normal intrauterin gebeliği olan 100 kadın çalışmaya dahil edildi. Gruplar kan Ca-125, E2 ve P seviyesi açısından karşılaştırıldı. Çalışma grubundaki 10 hastaya laparatomik yaklaşım, 90 hastaya laparaskopik yaklaşım yapıldı. Ektopik gebeliklerin 30’unda rüptür saptandı. 89 hastaya salpenjektomi yapılırken, 11 hastaya salpingostomi yapıldı.Bulgular: Kontrol grubuyla karşılaştırıldığında, ektopik gebelik grubunda Ca-125, E2, P ve E2-P oranı istatiksel olarak anlamlı düşük bulunmuştur. Ektopik gebelikler kendi içinde değerlendirildiğinde rüptüre olan ve olmayan ektopik gebelerin E2-P oranı, E2, P ve Ca-125 düzeyi arasında istatistiksel olarak anlamlı bir fark bulunamadı.Sonuç: Çalışmamızda değerlendirdiğimiz E2, P, E2-P oranı ve Ca-125 ölçümü ektopik gebelik tanısında faydalı markerler olmakla birlikte ektopik gebeliğin teşhisinde tek başına yetersizdir. Yine bu parametreler ektopik gebeliğin rüptüre olup olmadığının ayrımında yetersizdir.
Serum Ca-125, Estradiol And Progesterone Levels In Histopathologically Confirmed Ectopic Pregnancy Cases
Aim: To compare the serum, estradiol, progesterone, E2-P ratio and cancer antigen 125 levels between intrauterine pregnancy and ectopic pregnancy, to investigate the probable role of these markers for earlu diagnosis of ectopic pregnancy.Material and Methods: 100 patients who had diagnosis of histopathological confirmed ectopic pregnancy were defined as study group. 100 women with intrauterine, single, 6-8 weeks of gestation were defined as control group. Serum levels of CA-125, E2 and P were compared between groups. Ninety patients underwent laparoscopic surgery for ectopic pregnancy and 10 patients underwent laparatomy. Eighty-nine patients had salpingectomy and 11 of them had salpingostomy.Results: When we compared with control group, serum Ca-125, E2, P levels and E2-P ratio were lower in ectopic pregnancy group. The difference between these two groups were statistically significant. There is no statistically significant difference in E2-P ratios, E2, P and Ca-125 levels when the ectopic pregnancy group were divided into two groups as ruptured and non-ruptured.Conclusion: According to our findings, Ca-125, estradiol, progesterone levels and estradiol-progesterone ratio are useful but not satisfactory markers in the early diagnosis of ectopic pregnancy. Moreover, these parameters cannot be used in the diagnosis of rupture in ectopic pregnancy.
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