Gülsüm KADIOĞLU ŞIMŞEK, Fuat Emre CANPOLAT, H. Gözde KANMAZ KUTMAN, Sema ARAYICI, Halil İbrahim YAKUT, Özlem MORALOĞLU, Behzat ÖZKAN

Ankara İlinde Gebelerde 25-Hidroksi Vitamin D ve Paratiroid Hormon Düzeylerinin Kesitsel İncelemesi

Amaç: Vitamin D eksikliği gebelikte sık görülür. Çalışmamızda geniş bir Türk gebe kohortu değerlendirildi, gebelik süresince D vitamini eksikliği insidansı ve vitamin desteği alma oranlarının saptanması amaçlandı.Gereç ve Yöntemler: Haziran - Aralık 2013 tarihleri arasında hastanemiz gebelik izlem poliklinliğine başvuran ve gönüllü olan gebeler ile , yeme alışkanlıkları, yaşam tarzları ve vitamin takviyesi ile ilgili soruların yer aldığı bir anket gerçekleştirdi. Yazılı onamı alınan gebelerden D vitamini ve Paratiroid hormon düzeylerini ölçmek için kan örnekleri alındı.Bulgular: Toplam 1088 gebe analiz edildi. Ortalama D vitamini düzeyi 17.5 ± 9.9 ng / mL ve PTH 18.7 ± 11.4 pg / ml idi. Vitamin D eksikliği

Anahtar Kelimeler:

Vitamin D eksikliği, gebelik, Türkiye

A Crosssectional Study Of 25 Hydroxy Vitamin D And Parathroid Hormone Status During Pregnancy In Ankara Turkey

Aim: Vitamin D deficiency is common during pregnancy. We aimed to assess the incidence of vitamin D deficiency and vitamin supplementation rates during pregnancy in a relatively large cohort of pregnant Turkish women.Material and Methods: Pregnant women who admitted to the antenatal follow-up clinic between June and December 2013 fulfilled a survey which includes information about eating habits, lifestyleand vitamin supplementation. Blood samples were obtained to measure vitamin D and Parathyroid hormone levels from the pregnant who gave a written consent.Results: A total of 1088 pregnant women were analyzed. Mean vitamin D concentration was 17.5±9.9 ng/mL and PTH was 18.7±11.4 pg/ ml. Vitamin D deficiency

Keywords:

Vitamin D deficiency, pregnancy, Turkey,

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Holick MF. Vitamin D: evolutionary, physiological and health perspecti- ves. Curr Drug Targets2011; 12: 4-18.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911–30.
Xiao JP, Zang J, Pei JJ, Xu F, Zhu Y, Liao XP. Low maternal vitamin D sta- tus during the second trimester of pregnancy: a cross-sectional study in Wuxi, China. PLoS One 2015 6;10(2):e0117748.
Gür EB, Turan GA, Tatar S, Gökduman A, Karadeniz M, Celik G, et al. Theeffect of place of residenceandlifestyle on vitamin D deficiency in pregnancy: Comparison of easternand western parts of Turkey. J Turk GerGynecolAssoc 2014;15:149-55.
Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, et al. Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a prelimi- narystudy. Turk J Med Sci 2014; 44: 616-23.
https://www.saglik.gov.tr/TR,11158/gebelere-d-vitamini-destek-progra- mi.html
Marshall I, Mehta R, Petrova A. Vitamin D in the maternal–fetal–neonatal interface: Clinical implications and requirements for supplementation. J Matern Fetal Neonatal Med 2013;26:633–8
Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011;26:2341–57
Song SJ, Zhou L, Si S, et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013;8: e85081.
Shibata M, Suzuki A, Sekiya T, et al. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab 2011;29:615–20
Milman N, Hvas AM, Bergholt T. Vitamin D status during normal preg- nancy and postpartum. A longitudinal study in 141 Danish women. J Perinat Med 2011;40:57–61 .
Özdemir AA, Ercan Gündemir Y, Küçük M, Yıldıran Sarıcı D, Elgörmüş Y, Çağ Y, Bilek G.Vitamin D Deficiency in Pregnant Women and Their Infants.J Clin Res Pediatr Endocrinol 2018 Mar 1;10(1):44-50. doi: 10.4274/jcrpe.4706
Kılıcaslan AÖ, Kutlu R, Kilinc I, Ozberk DI.The effects of vitamin D supp- lementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters.J Matern Fetal Neonatal Med 2018 Jul;31(13):1727-1734
Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, Akin KO, Andiran N.Incidence of maternal vitamin D deficiency in a region of Ankara, Tur- key: a preliminary study.Turk J Med Sci 2014;44(4):616-23.
Aydogmus S, Kelekci S, Aydogmus H, Eriş S, Desdicioğlu R, Yilmaz B, Sağlam G.High prevalence of vitamin D deficiency among pregnant wo- men in a Turkish population and impact on perinatal outcomes.J Matern Fetal Neonatal Med 2015;28(15):1828-32
Parlak M, Kalay S, Kalay Z, Kirecci A, Guney O, Koklu E.Severe vitamin D deficiency among pregnant women and their newborns in Turkey.J Matern Fetal Neonatal Med 2015 Mar;28(5):548-51
van der Pligt P, Willcox J, Szymlek-Gay EA, Murray E, Worsley A, Daly RM.Associations of Maternal Vitamin D Deficiency with Pregnancy and Neonatal Complications in Developing Countries: A Systematic Review. Nutrients 2018 May 18;10(5). pii: E640. doi: 10.3390/nu10050640
http://www.who.int/elena/titles/vitamind_supp_pregnancy/en/
ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011 Jul;118(1):197-8. doi: 10.1097/AOG.0b013e318227f06b.
Canadian Pediatric Society. Vitamin D supplementation: Recommenda- tions for Canadian mothers and infants. J Paediatr Child Health 2007;12: 583–598.