Cemal KOÇAK, Tolgahan ÇATLI, Mehmet Ekrem ZORLU, Onur ÇORAKÇI, Selma TOSUN, Şebnem ÇALIK

COVİD-19 HASTALARINDA KULAK BURUN BOĞAZ SEMPTOMLARI VE HASTALIK ŞİDDETİNİN DEĞERLENDİRİLMESİ

Giriş: Bu çalışmanın amacı Covid -19 hastalarında kulak burun boğaz (KBB) semptomlarını ve hastalık şiddetini etkileyen faktörleri değerlendirmektir. Gereç ve Yöntem: Hastanemizde Mart 2020 - Nisan 2020 tarihleri arasında PCR testi ile Covid-19 tanısı konulan 102 hasta dahil edilerek retrospektif olarak yapıldı. Hastaların semptomları, demografik özellikleri, hastalığın klinik seyri ve ek hastalıkları not edildi. Bulgular: Çalışmaya yaş ortalaması 55.9 ± 18.4 (19-96) yıl olan 102 hasta dahil edildi. En sık semptomların öksürük (%53.9), ateş (%37.3) ve nefes darlığı (%32.4) olduğu gözlendi. En sık KBB semptomlarının koku alma bozukluğu (%29.4), tad alma bozukluğu (%26.5), boğaz ağrısı (%11.8) ve baş ağrısı (%6.9) olduğu tespit edildi. 65 yaş üzerinde olmanın entübe olma riskini 4.4 kat (1.6-12.1) arttırırken, ölüm riskini 5 kat arttırdığı görüldü (1.8- 13.7). Kronik hastalık varlığının entübe olma riskini 6 kat arttırırken (1.6-21.9), ölüm riskini 3.1 kat (1.1-9.3) arttırdığı tespit edildi. Sonuç: Çalışmamızda KBB semptomları değerlendirildiğinde rinit semptomlarının nadir görüldüğü, ancak sıklıkla koku ve tad alma bozukluğu görüldüğü ve bunlar dışında en sık karşılaşılan KBB semptomlarının kuru öksürük, boğaz ağrısı ile baş ağrısı olduğu izlendi. İleri yaş ve kronik hastalık varlığının hastalık şiddetine ilişkin en önemli risk faktörleri olduğu tespit edildi.

EVALUATION OF OTOLARYNGOLOGICAL SYMPTOMS AND DISEASE SEVERITY IN COVID-19 PATIENTS

Objective: The aim of this study is to evaluate otolaryngological symptoms and demographic features which effect disease severity in Covid-19 patients. Methods: This is a retrospective study of 102 patients with positive covid-19 PCR test who were treated in our hospital from March to April 2020. Patients’ symptoms, demographics, clinical course and comorbidities were collected and analyzed.Results: The study included 102 patients. The mean age of patients was 55.9 ± 18.4 years (19–96). The most common symptoms were cough (53.9%), fever (37.3%) and shortness of breath (32.4%). The most common otolaryngeal symptom was anosmia (29.4%), followed by ageusia (26.5%), sore throat (11.8%), and headache (6.9%). Being 65 years and older increased the risk of being intubated by 4.4 times (1.6–12.1) and the risk of mortality by 5.0 times (1.8–13.7). Having a chronic disease increased the risk of being intubated by 6.0 times (1.6–21.9) and the risk of mortality by 3.1 times (1.1–9.3) Conclusion: Smell and taste disturbances (anosmia and ageusia) were frequently observed, and the most common otolaryngology symptoms other than these were dry cough, sore throat, and headache. Age and the presence of chronic diseases were the most important factors determining the severity of the disease.

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1. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX et al. Clinical characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020; 382(18): 1708-20.
2. De Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nature Reviews Microbiology 2016; 14(8): 523-34.
3. Sedaghat AR, Gengler I, Speth MM. Olfactory Dysfunction: A highly prevalent symptom of COVID-19 with public health significance. Otolaryngol Head Neck Surg 2020; 163(1): 12-5.
4. Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory dysfunction and sinonasal symptomatology in COVID-19: prevalence, severity, timing, and associated characteristics. Otolaryngol Head Neck Surg 2020; 163(1): 114-20.
5. Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender differences in patients with COVID-19: focus on severity and mortality. Front Public Health 2020; 8: 152.
6. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395(10223): 507-13.
7. El-Anwar MW, Elzayat S, Fouad YA. ENT manifestation in COVID-19 patients. Auris Nasus Larynx 2020; 47(4): 559-64.
8. Vaira LA, Salzano G, Deiana G, De Riu G. Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 2020; 130(7): 1787.
9. Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. the prevalence of olfactory and gustatory dysfunction in COVID-19 Patients: A systematic review and meta-analysis. Otolaryngol Head Neck Surg 2020; 163(1): 3-11.
10. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020; 277(8): 2251-61.
11. Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 2020; 10(8): 944-50.
12. Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors and outcomes. J Med Virol 2021; 93(3):1449-58.
13. Turcotte JJ, Meisenberg BR, MacDonald JH, Menon N, Fowler MB, West M et al. Risk factors for severe illness in hospitalized Covid-19 patients at a regional hospital. PLoS One 2020; 15(8): e0237558.