B Vitaminleri ve Kemik Sağlığı

Kemik sağlığına etki eden birçok faktör vardır. Beslenme, kemik gelişimi ve sağlığının korunması için değiştirilebilir özellikteki en önemli faktördür. Kemik sağlığının korunması ve devamlılığında, kalsiyum ve D vitamininin rolü büyüktür. Bununla birlikte B vitaminlerinin homosistein düzeyleri üzerine etkili olması nedeniyle, B vitaminleri (özellikle folik asit, B12 ve B6) kemik sağlığı için önem arz eden mikro besin ögeleri olarak düşünülmektedir. Yüksek homosistein düzeyleri, kemik mineral yoğunluğunun azalmasına ve kemik dokuda mikro düzeyde değişimlere neden olarak kırık riskini artırmaktadır. Ancak yükselen homosistein düzeyi kırık oluşumunu açıklamada tek başına yeterli değildir. Kemik mineral yoğunluğu, kemik yapım ve yıkım sürecini içeren kemik döngüsü ve kollajen çapraz bağlar da kırık oluşumu üzerine etkilidir. B grubu vitaminler ve kemik sağlığına ilişkin çalışmalar sınırlıdır ve bulgular çelişkilidir.

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  • Salari, P., Abdollahi, M., Heshmat, R., Meybodi, H. A., & Razi, F. (2014). Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women. Daru, 22(1), 62.
  • Kakehasi, A. M., Carvalho, A. V., Maksud, F. A. N., & Barbosa, A. J. A. (2012). Serum levels of vitamin B12 are not related to low bone mineral density in postmenopausal Brazilian women. Revista brasileira de reumatologia, 52(6), 863-869. Mangels, A. R. (2014). Bone nutrients for vegetarians. The American journal of clinical nutrition, 100(Supplement 1), 469-475.
  • Bailey, R. L., Looker, A. C., Lu, Z., Fan, R., Eicher-Miller, H. A., Fakhouri, T. H., Mills, J. L., ve ark. (2015). B-vitamin status and bone mineral density and risk of lumbar osteoporosis in older females in the United States. The American journal of clinical nutrition, 102(3), 687-694.
  • Enneman, A. W., Swart, K. M., van Wijngaarden, J. P., van Dijk, S. C., Ham, A. C., Brouwer-Brolsma, E. M., van Meurs, J., ve ark. (2015). Effect of vitamin B12 and folic acid supplementation on bone mineral density and quantitative ultrasound parameters in older people with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial. Calcified tissue international, 96(5), 401-409.
  • Yang, J., Hu, X., Zhang, Q., Cao, H., Wang, J., & Liu, B. (2012). Homocysteine level and risk of fracture: a meta-analysis and systematic review. Bone, 51(3), 376-382. de Groot, C. P. G. M. (2013). Vitamin B 12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses. Journal of nutrition and metabolism, 2013, 1-19.
  • Morris, M. S., Jacques, P. F., & Selhub, J. (2005). Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone, 37(2), 234-242
  • Ruan, J., Gong, X., Kong, J., Wang, H., Zheng, X., & Chen, T. (2015). Effect of B Vitamin (Folate, B6, and B12) Supplementation on Osteoporotic Fracture and Bone Turnover Markers: A Meta-Analysis. Medical science monitor: international medical journal of experimental and clinical research, 21, 875.
  • Clarke, M., Ward, M., Dickey, W., Hoey, L., Molloy, A. M., Waldron, L., McNulty, H., ve ark. (2015). B-vitamin status in relation to bone mineral density in treated celiac disease patients. Scandinavian journal of gastroenterology, 50(8), 975-984. Dai, Z., & Koh, W. P. (2015). B-vitamins and bone health–a review of the current evidence. Nutrients, 7(5), 3322-3346.
  • Morris, M. S., Picciano, M. F., Jacques, P. F., & Selhub, J. (2008). Plasma pyridoxal 5′-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003–2004. The American journal of clinical nutrition, 87(5), 1446-1454.
  • van Wijngaarden, J. P., Swart, K. M., Enneman, A. W., Dhonukshe-Rutten, R. A., van Dijk, S. C., Ham, A. C., Zillikens, M. C., ve ark. (2014). Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. The American journal of clinical nutrition, 100(6), 1578-1586.
  • Baines, M., Kredan, M. B., Usher, J., Davison, A., Higgins, G., Taylor, W., Ranganath, L. R. ve ark. (2007). The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B 12 and vitamin B 6 with bone mineral density in postmenopausal British women. Bone, 40(3), 730-736.
  • Holstein, J. H., Herrmann, M., Splett, C., Herrmann, W., Garcia, P., Histing, T., Menger, M. D. ve ark., (2009). Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. The American journal of clinical nutrition, 90(5), 1440-1445.
  • Lopez, M. G., Bønaa, K. H., Ebbing, M., Eriksen, E. F., Gjesdal, C. G., Nygård, O., ... & Meyer, H. E. (2017). B‐vitamins and hip fracture. Secondary analyses and extended follow‐up of two large randomized controlled trials. Journal of Bone and Mineral Research, 32(10), 1981-1989.
  • Hermann, M., Widmann, T., & Hermann, W. (2005). Homocysteine--a newly recognised risk factor for osteoporosis. European Federation of Clinical Chemistry and Laboratory Medicine, 43(10), 1111-7.
  • Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., Kampman, E., ve ark. (2014). Effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. In Proceedings of The 4th Wellcome Trust Epigenomics of Common Diseases conference, 7(121), 1-14.
  • Stabler, S. P., & Allen, R. H. (2004). Vitamin B12 deficiency as a worldwide problem. Annu. Rev. Nutr., 24, 299-326.
  • Dhonukshe-Rutten, R. A., Lips, M., de Jong, N., Paw, M. J. C. A., Hiddink, G. J., van Dusseldorp, M., van Staveren, W. A., ve ark. (2003). Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. The Journal of nutrition, 133(3), 801-807.
  • Stone, K. L., Lui, L. Y., Christen, W. G., Atkinson, A. M. T., Bauer, D. C., Kado, D., ... & Manson, J. E. (2017). Effect of Combination Folic Acid, Vitamin B6, and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial. Journal of Bone and Mineral Research, 32(12), 2331-2338.