Cem PERK, Elif TAŞKIN, Serdar ÖZTEZCAN, Cenan OKTAY, Murat ŞAROĞLU

Serum nitrik oksit seviyesi deri transplantasyonu sonrasında akut rejeksiyonu gösteren bir kriter olabilir mi?

Nitrik oksit (NO), hücre immünolojisinde rol oynayan önemli bir immünoregülatör moleküldür ve organ transplantasyonlarında homogreft rejeksiyonları ile ilgisi olabileceği belirtilmektedir. Bu çalışmada deri transplantasyonu yapılan 39 adet Wistar albino sıçanda, serum NO düzeyleri ölçülerek, nitrik oksidin akut rejeksiyonu gösteren bir kriter olup olamayacağı araştırıldı. Denekler, 1. grup kontrol, 2. grup ototransplantasyon, 3. grup yalnızca homotransplantasyon ve 4. grup homotransplantasyonla birlikte bir immunsupressif (siklosporin) uygulanan şeklinde dört gruba ayrıldı. Tüm deneklerden 0., 5. ve 10. günlerde alınan serum örneklerinde NO seviyeleri ölçüldü. Gruplar birbirleri ile karşılaştırıldığında istatistik! olarak anlamlı bir fark bulunamadı. Sonuç olarak serum NO seviyesinin, deneysel deri homotransplantasyonunda akut rejeksiyonun saptanmasında güvenilir bir kriter olamayacağı kanısına varıldı.

Can the level of serum nitric oxide be a criterion showing acute rejection following experimental skin transplantation

Nitric oxide (NO) is an important immunoregulation molecule taking part in cell immu-notogy and it has been reported to be involved in homograft rejection in organ transplantation. In this study, serum levels of 39 Wistar Albino types rats with skin transplantation, were measured and nitric oxide was investigated whether to be a criterion showing acute rejection. Rats were seperated in four groups; 1: control group, II.: autotransplantated group, III.: only homotransplantation was made, IV.: homotransplantation + immunosuppression with cyclosporin. NO levels were measured in serum samples taken from the rat in 0.-5. and 10. days and no significant difference was observed when the groups were compared to each other. These re-sults suggest that levels of serum NO can not be a reliable criterion for showing acute rejection in experimental skin homotransplantation.

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