Yasemin AKINCI, Nurhan SEYAHİ, Sabahattin SAİP, Ayşegül GÜNDÜZ

TAKROLİMUS İLİŞKİLİ HEMORAJİK POSTERİOR REVERSİBL ENSEFALOPATİ SENDROMU: BÖBREK TRANSPLANTASYONU SONRASI GEÇ DÖNEMDE PREZENTE OLAN NADİR BİR OLGU

Organ ve doku transplantasyonu sonrası nadir görülen nörolojik komplikasyonlardan birisi olan posterior reversible ensefalopati sendromunun (PRES) gelişiminde, transplantasyon hastalarında sıkça kullanılan kalsinörin inhibitörleri gibi immünsüpresif ajanlar rol oynayabilmektedir. Sıklıkla transplantasyon sonrası erken dö- nemde görülen bu komplikasyon az sayıda olguda geç dönem- de meydana gelebilmektedir. Bu olgu sunumunda, kalsinörin inhibitörlerinin bu şiddetli ve dramatik yan etkisine dikkat çek- mek için, böbrek nakli sonrası geç dönemde gelişen, kuvvetle muhtemel takrolimus tedavisi ile ilişkili hemorajik PRES olgusunu sunmaktayız.

Anahtar Kelimeler:

PRES, tacrolimus, kalsinörin inhibitörleri, transplantasyon.

TACROLIMUS ASSOCIATED HEMORRHAGIC POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME: A RARE CASE IN THE LATE PERIOD AFTER RENAL TRANSPLANTATION

Immunosuppressive agents such as calcineurin inhibitors, which are commonly used in transplant patients may play a role in the development of posterior reversible encephalopathy syndrome (PRES), one of the rare neurological complications after organ and tissue transplantation. This complication, which is often seen in the early period after transplantation, occurs in the late period in a small number of cases. In this case report, to draw attention to this dramatic side effect of calcineurin inhibitors, we present a case of hemorrhagic PRES, which developed in the late period after kidney transplantation most likely associated with tacrolimus treatment.

Keywords:

PRES, tacrolimus, calcineurin inhibitors, transplantation,

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