Gürcan TÜRKYILMAZ, Gökçe Naz KÜÇÜKBAŞ, Emircan ERTÜRK, Şebnem TÜRKYILMAZ, Onur KARAASLAN, Hanım Güler ŞAHİN

PRENATAL FETAL NÖRAL TÜP DEFEKTİ TANISI KONULAN ANNELERDE SERUM B12 VE FOLAT DÜZEYLERİNİN KARŞILAŞTIRILMASI: VAKA- KONTROL ÇALIŞMASI

Amaç: Van Yüzüncü Yıl Üniversitesi ve Van Eğitim ve Araştırma Hastanesi’nde NTD tanısı koyulan ve sağlıklı fetüsü olan gebelerin B12 ve folat düzeyini karşılaştırdık. Gereç ve Yöntem: NTD tanısı koyulan 38 hasta ve 40 kontrol grubu çalışmaya dahil edildi. İstatistiksel analizde ki-kare testi ve Mann-Whitney U testi kullanıldı. Bulgular: NTD grubunda hiçbir hastada prekonsepsiyonel dönemde folik asit kullanımı yoktu ancak kontrol grubunda 4 (%10) hastada prekonsepsiyonel folik asit kullanımı mevcuttu ve bu fark istatistiksel olarak anlamlıydı (p=0,04). NTD grubunda 9 (%23.6), kontrol grubunda 32 (%80) hastada ilk trimesterde folik asit desteği alınmıştı ve bu istatistiksel olarak anlamlıydı (p=0,01). Ortalama B12 seviyesi NTD grubunda 248.7±65.4ng/ml, kontrol grubunda 239.3±27.5 saptandı ve bu fark anlamlı değildi (p=0,78). Ortalama folat seviyesi NTD grubunda 9.6±4.8 ng/ml, kontrol grubunda 9.8±3.9 ng/ml saptandı ve bu fark anlamlı değildi (p=0,62). Sonuç: Her iki grup arasında B12 ve folat seviyeleri farklı değildi ancak, sağlıklı bebeği olan grupta prekonsepsiyonel dönemde ve ilk trimesterde folik asit kullanımı NTD grubuna göre anlamlı olarak daha fazlaydı.

Anahtar Kelimeler:

Folat, nöral tüp defekti, prenatal, vitamin B12

COMPARISON OF MATERNAL B12 AND FOLATE STATUS IN PRENATALLY DIAGNOSED NEURAL TUBE DEFECTS: A CASE-CONTROL STUDY

Objective: To evaluate folate and B12 levels in fetuses who had been diagnosed with neural tube defects (NTDs) and healthy fetuses in Van Yüzüncü Yıl University and Van State Education and Research hospitals between March-August 2019. Material and Method: 38 pregnant women who had been diagnosed with fetuses with NTDs prenatally, and 40 healthy controls were recruited. The chi-square test and Mann-Whitney U test were employed to compare variables. Results: None of the women had taken folic acid preconceptionally in the NTD group. However, 4 (10%) women had taken folic acid supplementation in the preconception period in the control group, and this was significantly different among the groups (p=0.04). The women who had taken folic acid in the first trimester of pregnancy were 9 (23.6%) and 32 (80%) in cases and controls, respectively, and it was significantly different (p=0.01). The mean B12 level was 248.7±65.4ng/ml in cases and 239.3±27.5 ng/ml in controls, and there was no significance between the groups (p=0.78). The mean folate level was 9.6±4.8 ng/ml in cases and 9.8±3.9 ng/ ml in controls, and it was similar between the groups (p=0.62). Conclusion: We did not show difference in folate and B12 levels. However, folic acid intake in preconception or in the first trimester of pregnancy was significantly higher in women who have healthy babies compared to the NTD group.

Keywords:

Folate neural tube defect, prenatal, supplementation, vitamin B12,

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