Ramazan DENİZLİ, Önder SAKİN, Ali Doğukan ANGIN, Muzaffer Seyhan ÇIKMAN, Zehra Meltem PİRİMOĞLU

HPV TİP 16 VE 18 DIŞINDA POZİTİFLİĞİ OLUP SMEAR SONUCU NORMAL OLAN HASTALARIN KOLPOSKOPİK İNCELENMESİ

Amaç: Human Papilloma Virüs (HPV) tip 16 ve 18 dışında pozitifliği olup, smear sonucu normal olan hastaların kolposkopik muayene ve biyopsi sonuçlarını incelemek Gereç ve Yöntem: Çalışmamızda smear sonucu normal, ancak HPV tip 16-18 dışında pozitifliği olan ve Ocak 2017- Aralık 2017 tarihleri arasında hastanemizde kolposkopi yapılan 300 hasta incelendi. Hastalarımızın genel olarak kolposkopi endikasyonu postkoital kanama, ailede jinekolojik malignite öyküsü ve makroskopik şüpheli lezyon bulunması idi. Kolposkopi sırasında şüpheli lezyonu olmayan 39 hastaya (% 13) bir yıl sonra ko-test için kontrole çağrılırken, 261 hastaya kolposkopi kılavuzlu doku örneklemesi yapıldı.Bulgular: Histolojik inceleme sonuçları 186 hastada (%62) inflamasyon, 61 hastada (%20,33) CIN 1, 9 hastada (%3) CIN 2, 3 hastada (%1) CIN 3 ve 2 hastada (%0,67) servikal kanser olarak rapor edilmiştir. Sonuç: HPV tip 16-18 dışında pozitifliği olup smear sonucu normal olan hastalarda CIN 2 ve üstü lezyon, hatta kanser teşhisi konulabileceği unutulmamalıdır.

Anahtar Kelimeler:

Human papilloma virus (HPV), Smear tabakası, uterin servikal displazi, serviks kanseri, kolposkopi

COLPOSCOPIC EXAMINATION IN CYTOLOGY NEGATIVE WOMEN WHO TESTED POSITIVE FOR NON-16/18 HPV TYPES

Objective: To assess the colposcopic examination findings and biopsy results in women who tested positive for oncogenic Human Papilloma Virus (HPV) types other than HPV-16 and 18 while having otherwise normal Pap test results.Material and Method: This paper analyzes the results from a total of 300 women who tested positive for non-16/18 HPV types but had otherwise normal Pap test and underwent a colposcopic examination in our hospital between January 2017 and December 2017. The study subjects presented with postcoital bleeding, had a family history of cancer or exhibited macroscopic examination findings which were suspected to be malign. A co-test was scheduled one year later for 39 patients (13%) who had no lesions suspected of malignancy and a colposcopy-guided tissue sample was performed on 261 patients.Results: Histological examination results included inflammation (in 186 patients [62%]), CIN 1 (in 61 patients [20.33%]), CIN 2 (in 9 patients [3%], CIN 3 (in 3 patients [1%]) and cervical cancer (in 2 patients [%0.67]).Conclusion: One should keep in mind that a diagnosis of CIN 2 or more severe lesions or even cervical cancer can be made using a colposcopy-guided biopsy in women who test positive for non 16/18 HPV types but have otherwise normal Pap smear test.

Keywords:

Human papilloma virus (HPV), diagnosis, screening, colposcopy,

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