Gizem Gülsoy Toplan, Çağlayan Gürer, Afife Mat

Importance of Colchicum species in modern therapy and its significance in Turkey

Colchicum species, which are widely used as medication for many years, still remain important in treatment. Some of them are cultivated to be used for pharmaceutical industry. Tropolone alkaloids content of the species help in the treatment of FMF, gout, amyloidosis, cirrhosis, Behcet’s disease, psoriasis, Hodgkin lymphoma, myeloid leukemia and skin cancers. An economic and efficient synthesis method of Colchicum alkaloids haven’t found yet, that’s why colchicine and other alkaloids are obtained from plant source by extraction. The wide variety of Colchicum species in Turkey lead the researchers to investigate new sources of Colchicum rich in tropolone alkaloids. In our department, Colchicum species have been studied for more than 45 years and the contents and biological activities of the Colchicum species growing in our country are continuing to be studied today. This review was performed to summarize the investigations on Colchicum species in the world and to emphasize its importance in Turkey.

Anahtar Kelimeler:

Colchicum, tropolone alkaloids, colchicine, anticancer, gout, antiinflammatory

PDF

___

Ahern MJ, Reid C, Gordon TP, Mccredie M, Brooks PM, Jones M (1987) Does colchicine work? The results of the first controlled study in acute gout, Australian and New Zealand J of Med., 17: 301-304.
Aisen PS, Marin DB, Brickman AM, Santoro J, Fusco M (2001) Pilot Tolerability Studies of Hydroxychloroquine and Colchicine in Alzheimer Disease, Alzheimer Disease & Associated Disorders 15: 96-101.
Al-Fayyad M, Alali F, Alkofahi A, Tell A (2002) Determination of Colchicine Content in Colchicum Hierosolymitanum and Colchicum Tunicatum Under Cultivation, Nat. Product Lett.,16: 395-400.
Alali FQ, Tawaha K (2007) Determination of (–) -Demecolcine and (–) -Colchicine Content in Selected Jordanian Colchicum Species, Die Pharmazie, 1995: 739-42.
Alali FQ, Gharaibeh AA, Ghawanmeh A, Tawaha K, Qandil A, Burgess JP, Oberlies NH (2010) Colchicinoids from Colchicum crocifolium boiss.(Colchicaceae), Nat. product res., 24: 152-159.
Alali FQ, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Falkinham JO (2005) New Colchicinoids from a Native Jordanian Meadow Saffron, Colchicum brachyphyllum: Isolation of the First Naturally Occurring Dextrorotatory Colchicinoid, J Nat Products,, 68: 173-78.
Alexiou S (2013). The Genus Colchicum in Greece, Parnassiana archives, 1: 59-73. Baytop T (1999) Türkiye’de Bitkilerle Tedavi, Istanbul, Nobel Tıp Kitabevleri, 81-84. Baytop T, Özcöbek G (1970) Colchicum chalcedonicum, micranthum, szovitsii ve turcicum Alkaloitleri Üzerinde Araştırmalar. J Fac. Pharm of Istanbul University 6: 21-26.
Ben-Chetrit E, Berkun Y, Ben-Chetrit E, Ben-Chetrit A, (2004) The Outcome of Pregnancy in the Wives of Men with Familial Mediterranean Fever Treated with Colchicine, Seminars in Arthritis and Rheumatism, 34: 549-52.
Ben-Chetrit E, Levy M (1998) Colchicine: 1998 Update Seminars in Arthritis and Rheumatism 28: 48-59.
Borstad GC, Bryant LR, Abel MP, Scroggie DA, Harris MD, Alloway JA (2004) Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis. J Rheumatol, 31: 2429-2432.
Brossi A (1990) Bioactive Alkaloids. 4. Results of Recent Investigations with Colchicine and Physostigmine J Med Chem 33: 2311-2319.
Cairns HS, Spencer S, Hilson AJ, Rudge CJ, Neild GH (1994) 99mTc-DMSA imaging with tomography in renal transplant recipients with abnormal lower urinary tracts. Nephrol Dial Transpl , 9: 1157-1161.
Capraro HG, Brossi A (1984) Tropolonic Colchicum Alkaloids. The alkaloids 23: 1-70.
Cifuentes M, Schilling B, Ravindra R, Winter J, Janik ME (2006) Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs. Bioorganic & medicinal chemistry letters, 16: 2761-2764.
Cocco G, David CC, Pandolfi S (2010) Colchicine in Clinical Medicine. A Guide for Internists Eur J Intern Med 21: 503-8.
Das UN. (1993) Colchicine in Diabetes Mellitus J Assoc Physicians India 41: 213.
Dinç Düşen O, Sümbül H (2007) A Morphological Investigation of Colchicum L.(Liliaceae) Species in the Mediterranean Region in Turkey. Turk J Bot 31: 373-419.
Evans WC (2002) Trease and Evans. Pharmacognosy, WB Saunders.Edinburgh, London: 72.
Favari L, Pérez-Alvarez V (1996) Comparative Effects of Colchicine and Silymarin on CCl4-Chronic Liver Damage in Rats Arch Med Res 28: 11-17.
Goldstein RC, Schwabe AD (1974) Prophylactic Colchicine Therapy in Familial Mediterranean FeverA Controlled, Double-Blind Study nn Intern Med 81: 792-94.
Graening T, Schmalz HG (2004) Total Syntheses of Colchicine in Comparison: A Journey through 50 Years of Synthetic Organic Chemistry.” Angewandte Chemie (International ed. in English) 43: 3230-56.
Gupta, RS. (1985) Cross-Resistance of Vinblastine-and Taxol-Resistant Mutants of Chinese Hamster Ovary Cells to Other Anticancer Drugs Cancer treatment reports 69: 515-21.
Güner A, Özhatay N, Ekim T, Canbaşer KH (2000) Flora of Turkey and the East Aegean Islands, Vol. 11 (Edinburgh, UK: Edinburgh University Press). Le Hello C (2000) “In The Alkaloids; Cordell, GA, Ed.”
Husek A, Sütlüpinar N, Sedmera P, Voegelein F, Valka I, Šimánek V (1990) Alkaloids and Phenolics of Colchicum turcicum. Phytochemistry 29: 3058-60.
Kayaalp O S. (2002) Farmakolojiye Giriş, Rasyonel Tedavi Yönünden Tıbbi Farmakoloji (Ed SO Kayaalp) 10.” Baskı Hacettepe-Taş Kitapçılık Ltd. Şti. Ankara.
Khan, Haroon, Shafiq Ahmad Tariq, and Murad Ali Khan. 2011. “Biological and Phytochemical Studies on Corms of Colchicum Luteum Baker.” Journal of Medicinal Plants Research 5: 7031-35.
Kiraz S, Ertenli I, Arici M, Calgüneri M, Haznedaroglu I, Celik I, Kirazli S (1998) Effects of colchicine on inflammatory cytokines and selectins in familial Mediterranean fever. Clinical and experimental rheumatology, 16: 721-724.
Larsson S, Rønsted N (2014) Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry Current Topics in Medicinal Chemistry 14: 274-89.
Levy M, Spino M, Read SE (1991) Colchicine: A State of the Art Review Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 11: 196-211.
Anjum M, Brossi A. 1991. “Chemistry of Colchine.” Pharmacology & Therapeutics 49(1-2): 105-9.
Ondra P, Vicar J, Simanek V, Greenaway W, Sutlupinar N. (1994a). Alkaloids and phenolics of Colchicum kotschyi, Fitoterapia, 65: 178.
Ondra, P., Vicar, J., Simanek, V., Indrak, P., & Sutlupinar, N. (1994b). Alkaloids and phenolics of Colchicum macrophyllum, Fitoterapia, 65: 375-376.
Ondra, P et al. 1995. “Chromatographic Determination of Constituents of the Genus Colchicum (Liliaceae)1.” Journal of Chromatography A 704: 351-56.
Ondra, P., Simanek, V., Jirik, V., & Suetluepinar, N. (1995a). Alkaloids and phenolics of Colchicum bornmuelleri. Fitoterapia, 66(4), 375-376.
Ondra, P., Simanek, V., Jirik, V., & Suetluepinar, N. (1995b). Alkaloids and phenolics of Colchicum speciosum. Fitoterapia, 66(4).
Orhon B, (1982) Colchicum bivonae Guss.yumrularının alkaloitleri üzerinde araştırmalar, Unpublished PhD thesis, İstanbul University, İstanbul.
Pırıldar, S et al. 2010. “Chemical Constituents of the Different Parts of Colchicum baytopiorum and Their Cytotoxic Activities on K562 and HL60 Cell Lines.” Pharmaceutical Biology 48: 32-39.
Rodríguez Arnaiz R, América Castañeda S, Téllez GO. (2004) Detection of Mitotic Recombination and Sex Chromosome Loss Induced by Adriamycin, Chlorambucil, Demecolcine, Paclitaxel and Vinblastine in Somatic Cells of Drosophila Melanogaster in Vivo. Mutagenesis 19: 121-27.
Sanders PW. (1993) Potential Role of Colchicine in the Prevention of Cast Nephropathy from Bence Jones Proteins. In Kidney, Proteins and Drugs: An Update, Karger Publishers, 104-108.
Santavy F, Dvorackova S, Simanek V, Potesilova H (1983) Isolation and Identification of Alkaloids of the Subfamily Wurmbaeoideae Acta Universitatis Palackianae Olomucensis Facultatis Medicae 105: 63-110.
Sapra S, Bhalla Y, Sharma S, Singh G, Nepali K, Budhiraja A, Dhar KL (2013) Colchicine and Its Various Physicochemical and Biological Aspects Medicinal Chemistry Research 22: 531-47.
Schrek R, Messmore HL, Knospe WH, Stefani SS (1976) A Colchicine Sensitivity Test for Leukaemic Lymphocytes Scandinavian journal of haematology, 16: 357-64.
Sevim D, Senol FS, Budakoglu E, Orhan IE, Sener B, Kaya E (2010) Studies on Anticholinesterase and Antioxidant Effects of Samples from Colchicum L. Genus of Turkish Origin FABAD J. Pharm. Sci., 35: 195-201.
Sutlupinar, N. (1983) Türkiye’nin Sonbaharda Çiçek Açan Colchicum Türleri Üzerinde Araştırmalar Doğa, Bilim Derg. Temel Bilim, 7: 355-59.
Sutlupinar N, Husek A, Potesilova H, Dvorackova S, Hanus V, Sedmera P, Simanek V (1988) Alkaloids and Phenolics of Colchicum cilicicum1,2 Planta medica, 54: 243-45.
Sutlupinar N, Kilincli T, Mericli AH (2015) Colchicinoids from the Seeds of Colchicum umbrosum. Chemistry of Natural Compounds, 51, 512-514.
Ueda K, Cardarelli C, Gottesman MM, Pastan I (1987) Expression of a Full-Length cDNA for the human ‘MDR1’ gene Confers Resistance to Colchicine, Doxorubicin, and Vinblastine, Proceedings of the National Academy of Sciences, 84: 3004-8.
Verne, G (2003) Treatment of Chronic Constipation with Colchicine Randomized, Double-Blind, Placebo-Controlled, Crossover Trial, The American Journal of Gastroenterology, 98: 1112-16.
Wahba A, Cohen H (1980) Therapeutic Trials with Oral Colchicine in Psoriasis, Acta dermato-venereologica, 60: 515-20.
Wallace SL, Singer JZ, Duncan GJ, Wigley FM, Kuncl RW (1991) Renal Function Predicts Colchicine Toxicity: Guidelines for the Prophylactic Use of Colchicine in Gout, J of rheumatology, 18: 264-69.
Wetherley Mein G, Thomson AER, O’Connor TWE, Peel WE, Singh AK (1983) Colchicine Ultrasensitivity of Lymphocytes in Chronic Lymphocytic Leukaemia, British journal of haematology, 54: 111-20.
Yeşiltepe B, (2006) Colchicum bivonae Guss. tohumlarının alkaloitleri üzerinde araştrmalar, Unpublished MSc thesis, İstanbul University, İstanbul.
Yurdakul S, Mat C, Tüzün Y, Özyazgan Y, Hamuryudan V, Uysal Ö, Yazici H (2001) A Double blind Trial of Colchicine in Behçet’s Syndrome, Arthritis & Rheumatism, 44: 2686-92.
Zemer D, Livneh A, Danon YL, Pras M, Sohar E (1991) Long term Colchicine Treatment in Children with Familial Mediterranean Fever, Arthritis & Rheumatism, 34: 973-77.