A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines
DOI: 10.26650/IstanbulJPharm.2019.19002This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives. Cite this article as: Apaydın ÇB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.
Keywords:
Diacylhydrazines sulfanyl acid, reaction mechanism,
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- ISSN: 2548-0731
- Yayın Aralığı: Yılda 3 Sayı
- Başlangıç: 1965
- Yayıncı: İstanbul Üniversitesi
Sayıdaki Diğer Makaleler
Çağla Begüm APAYDIN, Zafer CESUR
Neriman ÖZHATAY, Şükran KÜLTÜR, Bahar GÜRDAL
Leyla ALACA, Fulya AYDINLI KULAK
Merve KURTAN YÜKSEL, Dilek ÖZTÜRK, Ezgi ÖZTAŞ, Gül ÖZHAN, Aylin ALTANLAR TÜRKER, Taner KORKMAZ, Alper OKYAR, Zeliha PALA KARA
Serpil UGRAŞ, Sultan ÜLGER, Pınar GÖÇ RASGELE
Ömür GENÇAY ÇELEMLİ, Mehmet ATAKAY, Kadriye SORKUN
Ayşe Esra KARADAĞ, Betül DEMİRCİ, Ömer ÇEÇEN, Fatma TOSUN
Abdullahi Rabiu ABUBAKAR, Mainul HAQUE
Serap İLİKAY, Ender COŞKUNPINAR, Özlem KURNAZ-GÖMLEKSİZ, Zehra BUĞRA, Allison P. ERONAT, Oğuz ÖZTÜRK, Hülya YILMAZ-AYDOĞAN