SORT1 rs599839 Polimorfizminin Lipit Profillerine Olan Etkisi: Tek Şehir Deneyimi

Amaç: VPS10p ailesinin bir reseptörü olan Sortilin-1(SORT1)’i kodlayan SORT1 geni 1p13.3’de lokalizedir. SORT1 genom çapında ilişkilendirme çalışmalarında (GWAS) hepatik lipit metabolizması ve düşük dansiteli lipoprotein-kolesterol (LDL-K) seviyeleri ile olan ilişkisinden dolayı koroner kalp hastalığı (KKH) oluşturma riski ile ilişkilendirilmiştir. SORT1 gen bölgesi üzerindeki çeşitli varyasyonlar lipit profilleri üzerinde farklı etkilere neden olmaktadır. Bizim bu çalışmadaki amacımız; Giresun ilinde SORT1 rs599839 gen varyantlarının KKH gelişimi ve lipit parametreleri üzerine bir etkisinin olup olmadığını belirlemektir.

Anahtar Kelimeler:

SORT1, Sortilin1, polimorfizm, Koroner kalp hastalığı, LDL-Kolesterol

Effect of SORT1 rs599839 Polymorphism on Lipid Profiles: A Single City Experience

Aim: The SORT1 gene encoding Sortilin-1 (SORT1), a receptor of the VPS10p family, is localized at 1p13.3. SORT1 has been associated with the risk of developing coronary heart disease (CHD) in genome wide association studies (GWAS) due to its association with hepatic lipid metabolism and low-density lipoprotein-cholesterol (LDL-C) levels. Various variations on the SORT1 gene region cause different effects on lipid profiles. Our aim in this study; To determine whether the SORT1 rs599839 gene variants have an effect on CHD development and lipid parameters in the Giresun province of Turkey.

Keywords:

SORT1, Sortilin1, polymorphism, Coronary heart disease, LDL-Cholesterol,

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