Gülşah ÖZTÜRK, Gökalp SİLAV, Said İNCİR, Ayça ARSLANHAN, Mustafa Ali AKÇETİN, Orkun Zafer TOKTAŞ, Deniz KONYA

Ratlarda Deneysel Spinal Kord Hasar Modelinde Genisteinin Nöroprotektif Etkisinin Araştırılması, Diffüz Tensor Görüntüleme ile Değerlendirilmesi

Amaç: Spinal kord hasarı (SKH), insidansı çok yüksek olmamasına rağmen, bu durumun sonuçları birey, aile ve toplum için son derece önemli sekellerle sonuçlanabilecek bir hastalıktır. Nöral hasar onarımı ile ilgili her geçen gün yeni çalışmalar umut vadetmekle birlikte SKH için kür olabilecek altın standart bir tedavi henüz yoktur. Bu çalışmada ratlarda ağırlık düşürme modeli kullanılarak oluşturulan spinal kord hasarı sonrası tedavi amaçlı verilen; bir tirozinkinaz inhibitörü olan Genistein (GEN) isimli fitoöstrojenin etkisi araştırılmış ve geç dönemde sayılı rat üzerindeki diffüzyon tensör görüntüleme (DTG) ile sonuçları değerlendirilmiştir.

Anahtar Kelimeler:

diffuz tensor görüntüleme, spinal kord hasarı, genistein, fraksiyonel anizotropi, rat, traktografi, omurilik travması

Investigation of Neuroprotective Effect of Genistein in Experimental Spinal Cord Injury Model in Rats, Evaluation with Diffuse Tensor Imaging

Aim: Spinal cord injury (SCI) is a wide spectrum of a devastating disease which has significant effects on individuals, families or society even though the incidence is low. Studies on neural tissue repair have huge progress in recent years but spinal cord injury still remains a troublesome condition with no definitive cure. In this study, we aimed to explore the effectiveness of Genistein (GEN), a phytoestrogen and tyrosine kinase inhibitor in a rat thoracic weight drop SCI model and to evaluate the long term results with diffusion tensor imaging (DTI), locomotion and histopathological changes.

Keywords:

spinal cord injury, genistein, diffusion tensor imaging, fractional anisotropy, tractography, rat, dti,

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