Onur ORAL, Anna ZUSA, Solmaz P. HASDEMİR, George NOMIKOS, S. Rana VAROL

Vitamin D ve Metabolik Fonksiyonları

Vitamin D,insanoğlu için en önemli vitaminlerden biridir ve ihtiyacının %95’i güneş ışınlarının cilde sentezlenmesiyle karşılanır.Vitamin D eksikliği özellikle kanser gibi bir çok hastalığa yol açabileceği için,yeterli bir seviyede vitamin D alanlar eğer egzersiz yaparlarsa bu riski azaltabilirler.Aynı zamanda vitamin D seviyesi yüksek olursa,leptin hormonu sayesinde daha az yemek yeneceği için obezite riski minimuma inecektir.Vitamin D reseptörleri yaklaşık olarak 40 dokuda vardır.Yağda çözünen vitamin D’nin en önemli etkisi kemik minerilizasyonu fosfor metabolizması ve kalsiyum üzerinedir.Vitamin D seviyesi düşük olan kişiler,yardımcı ilaçlar yerine vitamin D açısından zengin olan kaynakların besinlerinden sendromlar,bulaşıcı,otoimmün ve kardiyovasküler gibi bir çok hastalıkla ilişkisi olduğu bildirilmiştir.Gözlemsel çalışmalarda,endüstrileşmiş ülkeler de dahil olmak üzere dünyanın kuzey bölgelerinde vitamin D eksikliğinin çok yaygın olduğu anlaşılmıştır

Anahtar Kelimeler:

Vitamin D, Enerji Metabolizması, Leptin, Obezite, Egzersiz

Vitamin D and Its Metabolic Functions

Vitamin D is one of the most important vitamins for humankind and %95 of its requirements are acquired by synthesising solar rays on skin. While lack of vitamin D can lead to many diseases, especially cancer, the ones who get vitamin D in an appropriate level, can reduce this risk if they exercise. If, also, vitamin D level is high, obesity risk will be minimized because of eating less thanks to leptin hormone. Vitamin D receptors exist in approximately 40 tissues. The most imporant effect of vitamin D, which dissolves in fat, is on bone mineralization phosphorus metobolism and calcium. People whose vitamin D level is low, should take nourishment by sources rich in vitamin D instead of helper pills.

Keywords:

Vitamin D Energy, Energy Metabolism, Leptin, Obesity, Exercise,

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Akman AO, Tumer L, Hasanoglu A, Ilhan M, Caycı B.(2011): Frequency of vitamin D insufficiency in healthy children between 1 and 16 years of age in Turkey. Pediatr Int; 53: 968-973.
Arslanoğlu İ. (2009). Çocuk ve ergenlerde şişmanlık sorunu ve yaklaşım. Türk Pediatri Arşivi;44:115-9.
Block SR.(2004). Vitamin D deficiency is not associated with nonspesific musculoskeletal pain syndromes including fibromyalgia. Mayo Clin Proc;79:1585-6.
Braun-Moscovici Y, Toledano K, Markovits D, Rozin A, Nahir AM, Balbir-Gurman A. Vitamin D level: is it related to disease activity in inflammatory joint disease? Rheumatol Int 2011; 31: 493-499.
Bringhurst FR, Demay MB, Krane SM, Kronenberg HM, (2005). Bone and Mineral Metabolism in Health and Disease. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Internal Medicine. 16th edition. New York:MCGraw-Hill Companies, p. 2238-86.
De Luca HF, Cantorna MT. (2001).Vitamin D: its role and uses in immunology. FASEB J;15:2579-2585.
De Torrente de Jara G, Pecoud A, Favrat B.(2004). Musculoskeletal pain in female asylium seekers and hypovitaminosis D3. BMJ;329:156-7
Devaraj S, Jialal G, Cook T, et al. Low vitamin D levels in Northern American adults with the metabolic syn- drome. Horm Metab Res 2011;43:72-74.
Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ.(2004). Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med; 158: 531-537.
Fleck A. (1989). Latitude and ischaemic heart disease. Lancet:1:613.
Hatun Ş, Bereket A, Çalıkoğlu AS, Özkan B. (2003). Günümüzde D vitamini yetersizliği ve nütrisyonel rikets. Çocuk Sağlığı ve Hastalıkları Dergisi; 46: 224-241.
Harris S.(2002). Can vitamin D supplementation in infancy prevent type 1 diabetes? Nutr Rev;60:118-21.
Holick MF. (2002). Too little vitamin D in premenopausal women: why should we care?. Am J Clin Nutr, 76:3–4
Holick MF.( 2003). Vitamin D Deficiency: What a pain it is?. Mayo Clin Proc;78:1457-9.
Holick MF. (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr, 80:1678-88.
Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM.(2001). Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet;358:1500-3.
Javorsky BR, Maybee N, Padia SH, Dalkin AC. (2006). Vitamin D deficiency in gastrointestinal disease. Pract Gastroenterol; 36:52-72.
Malabanan A, Veronikis IE, Holick MF. (1998). Redefining vitamin D insufficiency. Lancet;351:805–806
McGill AT, Stewart JM, Lithander FE, Strik CM, Poppitt SD. (2008). Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome overweight and obesity. Nutr J;7:4.
Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. (2008). Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122: 398-417.
Muszkat P, Camargo MB, Griz LH, (2010). Lazaretti-Castro M. Evidence-based non-skeletal actions of vitamin D. Arq Bras Endocrinol Metabol, 54:110-117.
Narvaez, C. J., Matthews, D., Broun, E., Chan, M., & Welsh, J. (2009). Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology, 150(2), 651-661.
Nemere I, Carson F. (1998). Membrane receptors for steroid hormones: a case for spesific cell surface binding sites for vitamin D metabolites and estrogens. Bio- chem Biophys Res Com;248:442-449.
O’Connell TD, Berry JE, Jarvis AK, et al. 1,25-dihy- droxyvitamin D3 regulation of cardiac myocyte prolifer- ation and hypertrophy. Am J Physiol 1997;272:H1751- H1758.
Özkan B, Döneray H.(2011). D vitamininin iskelet sistemi dışı etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi;54:99-119.
Patel S, Farragher T, Berry J, Bunn D, Silman A, Symmons D. Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis Rheum 2007; 56: 2143-2149.
Pfeifer, M., Begerow, B., Minne, H. W., Suppan, K., Fahrleitner-Pammer, A., & Dobnig, H. (2009). Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporosis International, 20(2), 315-322.
Pelajo CF, Lopez-Benitez JM, Miller LC.(2010). Vitamin D and autoimmune rheumatologic disorders. Autoimmun Rev; 9: 507-510.
Reginato AJ, Falasca GF, Pappu R, McKnight B, (1999). Agha A Musculoskeletal manifestation of osteomalacia: report of 26 cases and literature review. Semin Artritis Rheum, 28:287-304.
Rosen CJ, Adams JS, Bikle DD, et al. The Nonskel- etal effects of Vitamin D: an Endocrine Society Scien- tific Statement. Endocrine Reviews 2012;33:456-492.
Rossini M, Maddali Bongi S, La Montagna G, et al. Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther 2010; 12: R216.
Schwartz MW, Woods SC, Porte D, Jr., Seeley RJ & Baskin DG (2000). Central nervous system control of food intake. Nature 404 661-671.
Snijder, M. B., van Dam, R. M., Visser, M., Deeg, D. J., Dekker, J. M., Bouter, L. M., ... & Lips, P. (2005). Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. The Journal of Clinical Endocrinology & Metabolism, 90(7), 4119-4123.
Thomas MK, Lloyd-Jones DM, Thadhani RI, (1998). Hypovitaminosis D in medical inpatients. N EnglJ Med.;338:777–83.
Zemel, M. B., Reddy, S., & Sowers, J. R. (1991). Insulin Attenuation of Vasoconstrictor Responses to Phenylephrine in Zucker Lean ana Obese Rats.American journal of hypertension, 4(6), 537-539.