Initially, it should be noted that transplantation is the last method treatment. Expert and legal team is needed for such a complex procedure because it is a legal legal process. The question is, is the role of a nurse crucial in transplantation? The attitude of health workers about organ donation can either facilitate or hinder the process of organ donation.Many studies have shown that their role is significant. They can act as coordinators between the treatment team, but also between donors and their families, but also the recipient of the organ. People have different attitudes reference to organ donation. The degree of readiness to be registered as organ donors have been associated with a wide range of humanitarian and the charity of the feelings includes a plurality of factors. These factors are a complete willingness to donate the organ, but also the dilemma of various abuses, empathy and fear what will happen to these after their death. The nurse must also be included in the transplantation law, because the training of nurses for intensive care is extremely important in the organ donation process. In many countries, nurses are not members of the team for transplantation because it is considered that they lack the required level of knowledge. Education about the transplantation of organs should be included in the mandatory training and all the nurses have to finish it, in Serbia. Developing a more positive attitude of nurses towards organ transplantation, improving knowledge and changing beliefs should increase the total number of organ donations.