The aim of this study is to reveal whether Psychological Capital (PC) has a positive effect in COCB that push employees to a cynical attitude and behavior. In other words, this study examines the role of high and low level of PC between COCB and Organizational Cynicism (OC). A basic food producer enterprise located in the province of Gaziantep and in the Istanbul Chamber of Industry (ICI) 500 list of 2019 was selected for the research within the scope of the study. The data required for the research were collected using the questionnaire method and the data set of 305 people was analyzed with the SPSS 22 statistics program. The negative mediating role of PC in the impact of the COCB on OC and its sub-dimensions was tested by Multiple Regression Analysis. As a result of the analysis, it was found statistically significant that PC meaningfully moderation the COCB, however, the decreased COCB relatively less increased OC. In addition, it has been found statistically significant with Hierarchical Regression Analysis that PC has a moderatory role in the effect of COCB on OC. As a result, the mediation and moderation role of PC in the effect of COCB on OC was evaluated within the framework of the system approach and it is considered that the application of the measures to be taken at the same time to increase the PC and to decrease the COCB and OC will have a synergistic effect.