Abstract: Background: Coronary heart disease (CHD) is a main cause of mortality due to cardiovascular diseases. Hypertriglyceridemia (HTG) is a multifactorial condition implicated in the pathogenesis of CHD. Serum triglyceride (TG) levels were routinely obtained under fasting conditions; however, recent evidences implicate that postprandial triglyceride levels may be more important for CHD risk. Aim: Aim of this study was to investigate the effect of rosuvastatin on fasting and postprandial TG levels in the patients with borderline-high TG levels. Methods: 51 patients (18-75 years old; 26 female) with LDL-c between 100 and 160 mg/dL and triglyceride levels between 150 and 300 mg/dL were included in this study. Basal fasting and postprandial lipid profile and hsCRP levels of the patients were obtained and patients were requested to take 10 mg/day rosuvastatin for one month. At the end of one month, the measurements were repeated. Results: Rosuvastatin significantly decreased both fasting and postprandial TG levels compared to basal levels (p