Climate change associated factors including temperature increases, changes in rain fall pattern and occurrence of pest and diseases negatively influence agricultural production, productivity and quality. Climate change effects particularly in region suffer persistent soil and water resource scarcity significantly increases production risk. The effects of climate change on agriculture may depend not only on changing climate condition, but also on the ability to adapt through changes in technology and demand for food. Biotechnology positively reduced the effects of climate change by using modern biotechnology. Modern biotechnology through the use of genetically modified stress tolerant and high yielding transgenic crops also stand to significantly counteract the negative effects of climate change. Convectional biotechnology such as bio fertilizer and energy efficient farming are among reasonable options that could solve problems of climate change.  Also this paper deals with the modern technology like omics, system biology and other technology has discussed to combat aboitc stress of plant. Finally, the paper highlighted the current challenges and future perspective of biotechnology for climate change adaptation and mitigation.