Basra Deniz OBAY, Hakkı Murat BİLGİN, Ezel TAŞDEMİR, Yaşar YILDIRIM, Abdurrahman ŞERMET, Yüksel KOÇYİĞİT

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The Role of Growth Hormone in Regulation and Secretion of Ghrelin

The Role of Growth Hormone in Regulation and Secretion of Ghrelin

Background: Ghrelin is a novel growth hormone (GH) releaser acylated peptide that has recently been purified from stomach and potently binds to the GH secretagogue receptor. In rats, fasting leads to elevated serum GH concentrations. Age-related decreases in energy expenditure have been associated with the loss of skeletal muscle and decline of food intake, possibly through a mechanism involving changes of GH secretion and feeding behavior. Ghrelin releases GH in vitro and in vivo in animal models, however its actions and specificity in humans are unknown. Method: We investigate the relationship between age-related changes of growth hormone secretion and/or food intake and ghrelin function. Ghrelin (10 nmol/kg body weight) was administered intravenously to male 3-, 12-, 24-and 27-month-old Wistar adult rats, after which growth hormone concentrations and 2 h food intake were measured. Results: Intravenous administration of ghrelin to rats increased food intake in all generations. In addition ghrelin administration elicited a marked increase in plasma GH levels, with the peak occurring 15 min after administration. Conclusion: These changes in serum ghrelin concentrations during fasting were followed by similar, profound changes in serum GH levels. These data indicate that ghrelin is the main driving force behind the enhanced GH secretion during fasting.
Keywords:

Ghrelin, growth hormon, food intake,

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International Archives of Medical Research-Cover
  • ISSN: 2146-6033
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 2011
  • Yayıncı: Veysi AKPOLAT
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