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TİMOLOL/BRİNZOLOMİD KOMBİNASYONU İLE TİMOLOL/DORZOLOMİD KOMBİNASYONUN GÖZ TANSİYONU AÇISINDAN KARŞILAŞTIRILMASI

Amaç: Bu çalışmanın amacı timolol/dorzolamid vetimolol/brinzolamid sabit kombinasyon ilaçlarınıngöz içi basıncı üzerine etkisini karşılaştırmaktır.Gereç ve Yöntem: Bu retrospektif bir çalışmadır.Monoterapiye rağmen intraoküler basıncı yüksekolan ve kombinasyon tedavisine geçilen primer açıkaçılı glokom hastaları çalışmaya dahil edildi. .Toplam 50 hastanın 50 gözü çalışmaya alınmıştır(timolol /dorzolamid grubunda 26, timolol/brinzolamid grubunda 24 hasta). İridokorneal açıdasineşi olmayan, hikayesinde başka herhangi bir gözhastalığı olan veya herhangi bir göz ameliyatıgeçiren hastalar çalışmaya dahil edilmemiştir.Kaydedilmiş olan 4.hafta ve 4.ay göz içi basınçdeğerleri karşılaştırıldı.Bulgular: Bazal intraoküler basınç değeritimolol/dorzolamid grubunda 23,2±3,3 (17-28mmHg), timolol/brinzolamid grubunda ise 23,1±2,8(17-28 mmHg) olarak bulundu. 4.hafta sonundaelde edilen intraoküler basınç değerleri timolol/dorzolomid grubunda 15,3 ±2,3 (11-20mmHg),timolol/brinzolomid grubunda ise 15,8±2,7(11-19mmHg) idi. Bu değerler arasında istatistikselolarak anlamlı fark bulunamadı. 4.ay sonunda eldeedilen İOB değerleri timolol/dorzolamid grubunda15,8±3,1 (11-21mmHg), timolol/brinzolomidgrubunda ise 16,1±2,8 (12-22mmHg) olarakbulundu. Bu değerler arasında istatistiksel olarakanlamlı fark bulunamadı.Sonuç: Her iki ilaçta intraoküler basıncı başarılı birşekilde düşürmüştür fakat 4.hafta ve 4.ay değerleriarasında istatistiksel olarak anlamlı bir fark yoktur.

Anahtar Kelimeler:

Timolol/Brinzolomid, Timolol/Dorzolomid, Göz Tansiyonu

Comparison the effect of timolol/brinzolomid and timolol/ dorzolamid fixedcombination drugs on intraocular pressure

Objective: The aim of this study is to compare the effect timolol/brinzolomid fixed-combination drugs on intraocular pressure. Materials and Methods: This is a retrospective study. The primary open angle glaucoma patients that were switched to fixed-combination drugs due to high intraocular pressure despite monotherapy were included to the study. The intraocular pressure records of 4.week and 4.month were compared. Results: The baseline intraocular pressure levels were timolol/dorzolamid group and 23,1±2,8 (17-28 mmHg) in timolol/brinzolamid group. After 4.weeks of combination treatment intraocular pressure levels were 15,3 ±2,3 mmHg (1120mmHg) in timolol/ dorzolomid and 15,8±2,7(1119mmHg) in timolol/brinzolomid. After 4.nmonths of combination treatment intraocular pressure levels were 15,8±3,1 (11-21mmHg) in timolol/dorzolamid group timolol/brinzolomid group. There statistically significant difference between the groups. Conclusion: Both fixed combination drugs decreased the intraocular pressure successfully but there was no statistically significant difference between intraocular pressure levels at 4.week and 4.month. Key dorzolamid

Keywords:

timolol/brinzolomid, timolol/ dorzolamid, intraocular pressure,

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