Multipl skleroz hastalarında ganglion hücre kompleks kalınlığı ile maküler kalınlık arasında ilişki var mı?

Amaç: Optik Nörit (ON), Multipl Skleroz’un (MS) en sık saptanan göz bulgusudur. ON, aksonal kayba yol açıp hem Optik Koherens Tomografi (OCT) ve hem de görsel uyarılmış potansiyallerde (VEP) anormalliklere neden olabilmektedir. Bu çalışmada OCT ile Retina Sinir Lifi Tabakası (RSLT), Ganglion Hücre Kompleksi (GCC) ve maküler kalınlığı ölçülerek, bu parametreler, klinik olarak ON öyküsü olan ve olmayan MS hastaları ve sağlıklı bireylerle karşılaştırıldı. Ayrıca bu değerlerin VEP bulguları ve klinik bulgularla korelasyonunun olup olmadığı incelendi, aksonal kaybın bir belirteci olarak kullanılıp kullanılamayacağını değerlendirme hedeflendi. Yöntem: Çalışmaya 18-55 yaşları arasında, 49 MS hastası (98 göz) ve 30 sağlıklı kontrol grubu (60 göz) dahil edildi. Görme keskinliği, renkli görme, VEP ve OCT ölçümü yapıldı. Bulgular: ON öyküsü olan gözlerde daha fazla olmak üzere tüm MS hastalarında RNFL, GCC, makula (süperior dış katman hariç) ve fovea kalınlığı ölçümleri istatistiksel olarak anlamlı olarak daha ince bulundu. Sonuç: ON olmayan gözlerde de bu değerlerde bozulma tespit edilmesi OCT’nin sadece ON geçiren MS hastalarında değil tüm hastalarda kullanılmasının fayda sağlayacağını ve OCT de bakılan parametre sayısı artırıldıkça ayırt edici özelliğinin artacağını ve aksonal hasarın MS hastalarında daha iyi değerlendirebileceğini düşündürdü.

Anahtar Kelimeler:

Multipl Skleroz, Maküla, Retina Ganglion Hücresi

Is there a relationship between the ganglion cell complex thickness and macular thickness in patients with multiple sclerosis?

Objective: Optic neuritis (ON) is the most common ocular finding of multiple sclerosis (MS). ON can cause axonal loss and abnormalities in both optical coherence tomography (OCT) parameters and visual evoked potentials (VEPs). In this study, the retinal fiber layer (RNFL), ganglion cell complex (GCC) and macular thicknesses were measured with OCT and compared between MS cases with and without a clinical history of ON and healthy individuals. In addition, it was examined whether these values were correlated with VEP and clinical findings and whether they could be used as a marker of axonal loss. Method: The study included 49 patients with MS (98 eyes) and 30 healthy controls (60 eyes) aged 18-55 years. Visual acuity, color vision, VEP, and OCT measurements were evaluated. Results: RNFL, GCC, macula (except the superior outer layer), and foveal thickness measurements were statistically significantly thinner in all MS patients, especially in eyes with a history of ON. Conclusion: Due to the detection of deterioration in these values in non-ON eyes, it was concluded that the use of OCT in all patients, not only in MS patients with ON, would be beneficial, and as the number of parameters measured in OCT is increased, its distinctive feature will improve and axonal damage can be better evaluated in MS patients.

Keywords:

Multiple Sclerosis, Macula, Retinal Ganglion Cell,

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