The investigation of incidence and radiological findings of gastrointestinal stromal tumor as a rare cause of abdominal mass
The investigation of incidence and radiological findings of gastrointestinal stromal tumor as a rare cause of abdominal mass
Aim: The aim of the present study was to evaluate the investigation of incidence and radiological findings of gastrointestinal stromal tumors (GIST) as a rare cause of abdominal mass, with current literature review.Material and Methods: Between February 2011 and May 2016, a total of 4,443 patients who underwent abdominal multislice computed tomography and magnetic resonance imaging due to the clinical indications for abdominal pain, abdominal swelling-mass were analyzed in our hospital. The retrospective cross-sectional study included forty-five patients, who were subsequently diagnosed with GIST histopathologically. Results: GIST was identified in 45 (1%) patients. Of the total 45 patients, 21 (47%) were men and 24 (53%) were female. The mean age was 55 years, ranging from 35 to 73 years. As a result of radiological examinations, the tumor location was stomach in 22 cases (49%), small intestine in 12 cases (27%) and colon in 9 cases (20%). The retroperitoneal localization was also found in 2 cases (4%). The average size of the lesions ranged between 2 and 15 cm. Malignant degeneration and omental metastasis were seen in 11 (24%) and 7 cases (16%) respectively.Conclusion: GIST is a rare cause of abdominal mass with an incidence of 1% in our region. They are most commonly localized in the stomach, rarely in the omentum/mesentery and retroperitoneum. The Malignant transformation is not frequent. Diagnosis and evaluations of mass can be made successfully by radiological imaging modalities.
___
- Ayşegül Akdoğan Gemici, Osman Köneş, Ali Kocataş, Ahmet Tan Cimilli. Gastrointestinal Stromal Tümörlerin Klinik, Radyolojik ve Patolojik Bulgularının Değerlendirilmesi. Fırat Tıp Dergisi 2013;18(4):219-23.
- Yüksel Küçükzeybek, Betül Bolat Küçükzeybek, Abdullah Altıntaş, Cengiz Demir. Gastrointestinal Stromal Tümörlerin Medikal Tedavisinde Güncel Açılımlar. Van Tıp Dergisi 2010;17:23-31.
- Van Den Abbeele AD, Badawi RD. Use of positronemission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors. Eur J Cancer 2002;38:S60-5.
- Blay JY, Bonvalot S, Casali P, Choi H, Debiec-Richter M, Dei Tos AP, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Ann Oncol 2005;16(4):566-78.
- Hong X, Choi H, Loyer EM, Benjamin RS, Trent JC, Charnsangavej C. Gastrointestinal stromal tumor: role of CT in diagnosis and in response evaluation and surveillance after treatment with imatinib. Radiographics 2006;26(2):481-95.
- Bucher P, Villiger P, Egger JF, Buhler LH, Morel P. Management of gastrointestinal stromal tumours: from diagnosis to treatment. Swiss Med Wkly 2004;134:145-53.
- Selcukbiricik F, Tural D, Oztürk MA, Dervisoglu S, Sager S, Hız M, et al. Gastrointestinal stromal tumor of the rectum with scapular metastasis: a case report. J Med Case Rep 2012;6:145.
- Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002;33(5):459-65.
- Bolukbasi H, Nazli O, Tansug T, Bozdag AD, Isgiider AS, Yaman I, et al. Gastrointestinal stromal tumors (GISTs): analysis of 20 cases. Hepatogastroenterology 2006;53:385-8.
- Mustafa Şit, Fatih Kaya, Edip Erdal Yilmaz, Gülali Aktaş. Mide Fundusunda Nadir Yerleşimli Gastrointestinal Stromal Tümörü: Olgu Sunumu. Kocaeli Tıp Dergisi 2012;1(2):31-4.
- Goettsch WG, Bos SD, Breekveldt-Postma N, Casparie M, Herings RM, Hogendoorn PC. Incidence of gastrointestinal stromal tumours is underestimated: results of a nation-wide study. Eur J Cancer 2005;41(18):2868-72.
- Nilsson B, Bümming P, Meis-Kindblom JM, Oden A, Dortok A, Gustavsson B, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era--a population-based study in western Sweden. Cancer 2005;103(4):821-9.
- Ma GL, Murphy JD, Martinez ME, Sicklick JK. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomarkers Prev 2015;24:298-302.
- Reddy P, Boci K, Charbonneau C. The epidemiologic, health-related quality of life, and economic burden of gastrointestinal stromal tumours. J Clin Pharm Ther 2007;32(6):557-65.
- Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol 2005;100(1):162-8.
- Takizawa I, Morishita H, Matsuki S, Komeyama T, Emura I, Hara N. Primary gastrointestinal stromal tumor in the retroperitoneum. Int J Urol 2006;13(9):1245-8.
- Engin G, Asoglu O, Kapran Y, Mert G. A gastrointestinal stromal tumor with mesenteric and retroperitoneal invasion. World J Surg Oncol 2007;5:121.