Ranitidin uygulanmasını takiben sıçanların Paneth hücrelerinin histolojik incelenmesi

Ranitidin mide içeriğinin (kimus) pH'ını değiştiren H2 reseptör blokörüdür. Ortamın asidik olması bakterisid etkiyi azaltır. Asidik ortamda bakteri yaşayamaz. Ortamın pH'ını değiştiren ranitidin nedeniyle bakteriler barsak ortamına rahatça girerler. Özellikle ince barsağın ileum parçasında barsak florasının korunmasında rol oynayan Paneth hücrelerinin, lizozim içeren salgı granüllerini boşaltarak, bakterisid etkiyi ortadan kaldırmaya çalıştığı bilinmektedir. Amaç, ranitidinin H2 reseptör blokör özelliğinden yararlanıp, kimusun bakteri yaşamasına izin veren alkali ortamını oluşturarak, Paneth hücrelerindeki değişiklikleri histolojik olarak incelemektir. Yapılan çalışmada, Paneth hücrelerinin aktifleşip, aktivitesini artırıp, degranülasyona uğradığı saptanmıştır.

Histological observation of the Paneth cells following ranitidin induction in rats

Ranitidin is a blocking agent for histamine H2 receptors that changes pH of the chyme. Bacteria do not live in the acidic miliue. Bacteria pass through the intestine by way of changing the pH of the miliue. Especially, Paneth cells are replaced at the distal ileum region of the intestine and manufacture the antibacterial agent lysozyme, protecting the intestinal flora by discharging the granules containing lysozyme. Aim: The Paneth cell changes are examined histologically, to assure miliue permission to the bacterial living by use of H2 receptor blocking. In this study, the Paneth cells had been assigned to degranulation by way of increasing cellular activity.

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