Dilara KAMAN, Funda Gulcu BULMUS, Gamze KIRKIL, Selda TELO

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Aim: The aim of this study is to investigate the changes in platelet indexes, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PC), in patients with acute pulmonary embolism (PE), in addition to evaluating the diagnostic value in clinical forms.Material and methods: The study consisted of 84 patients with PE and the control group consisted of 40 healthy subjects. PE patients were divided into two groups in accordance with the clinical forms as 60 submassive and 24 nonmassive. The differences in platelet count, MPV, PDW, PC, D-dimer, and other indicators were analyzed between the two groups. Venous peripheral blood samples to measure the MPV, PDW and PC were acquired on admission.Results: MPV levels were found to be statistically higher in the submassive group compared to the nonmassive group and the control group (p

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Chung T, Connor D, Joseph J, Emmett L, Mansberg R, Peters M, et al. Platelet activation in acute pulmonary embolism. J Thromb Haemost 2007;5(5):918-24.
Kostrubiec M, Łabyk A, Pedowska-Włoszek J, HrynkiewiczSzyman´ska A, Pacho S, Jankowski K, et al. Mean platelet volume predicts early death in acute pulmonary embolism. Heart 2010;96(6):460-5.
Gunay E, Sarinc Ulasli S, Kacar E, Halici B, Unlu E, Tünay K, et al. Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism? Clin Respir J 2014;8(1):33-40.
Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011;16(2):86-9.
Hilal E, Neslihan Y, Gazi G, Sinan T, Zeynep Ayfer A. Does the mean platelet volume have any importance in patients with acute pulmonary embolism?. Wien Klin Wochenschr 2013;125(13-14):381-5.
Varol E, Icli A, Uysal BA, Ozaydin M. Platelets indicates in patients with acute pulmonary embolism. Scand J Clin Lab Invest 2011;71(2):163-7.
İn E, Deveci F, Kaman D, Özdemir C, Sökücü SM, Kuluöztürk M, et al. The importance of mean platelet volume and red cell distribution width in acute pulmonary embolism. Acta Medica Mediterranea 2015;31:1209.
Gulcan M, Varol E, Etli M, Aksoy F, Kayan M. Mean platelet volume is increased in patients with deep vein thrombosis. Clin Appl Thromb Hemost 2012;18(4): 427-30.
Canan A, Halicioglu SS, Gurel S. Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis. J Thromb Thrombolysis 2012;34(2):283-7.
Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets 2013;24(8):590-3.
Demir N, Peker E, Ece İ, Ağengin K, Bulan KA, Tuncer O. Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus? J Matern Fetal Neonatal Med 2016;29(12):1915-8.
Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn 2012;122(6):284-90.
Erdogan D, Tayyar S, Icli A, Uysal BA, Varol E, Ozaydin M, et al. Elevated mean platelet volume is associated with impaired coronary microvascular function in patients with idiopathic dilated cardiomyopathy. Platelets 2012;23(3):177-83.
Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14(1):28-32.
Sevuk U, Bahadir MV, Altindag R, Baysal E, Yaylak B, Ay N, et al. Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis. Ther Clin Risk Manag 2015;11:1243-9.
Braekkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø Study, Tromsø, Norway. J Thromb Haemost 2010;8(1):157-62.
Klovaite J, Benn M, Yazdanyar S, Nordestgaard BG. High platelet volume and increased risk of myocardial infarction: 39,531 participants from the general population. J Thromb Haemost 2011;9(1):49-56.
Yardan T, Meric M, Kati C, Celenk Y, Atici AG. Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism. Medicana (kaunas) 2016;52(2):110-15.
Sanchez O, Planquette B, Roux A, Gosset-Woimant M, Meyer G. Triaging in pulmonary embolism. Semin Respir Crit Care Med 2012;33(2):156–62.
Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D Galie` N, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J 2014;35(43):3033-69.
Wang M, Zhang J, Ji Q, Yang Q, Zhao F, Li W, et al. Evaluation of platelet distribution width in chronic obstructive pulmonary disease patients with pulmonary embolism. Biomark. Med 2016;10(6):587-96.
Huang J, Chen Y, Chai. Z, Chen P. Diagnostic value of platelet indexes for pulmonary embolism. Am J Emerg Med 2015;33(6):760-3.