Oxidative DNA Damage Protective Ability of Punica granatum

Oxidative stress can cause harm to macromolecules such as lipid, protein and DNA. Therefore, therehas been a huge attention to find out organic sources with antioxidant properties to prevent oxidative stress-induceddamage. Literature data on this subject have suggested that consuming food which contain phenolic compoundsdecreases the risk of several diseases and protection against certain forms of cancer. Punica granatum L., knownas pomegranate belongs to the family Punicacea. It is one of the fundemantel fruit, cultivated in Mediterraneancountries. The present study was designed to investigate the total phenolic content of the Derik pomegranate peeland juice, and their protective ability against DNA damage induced by Fenton System. The result indicates thatboth juice and peel have a significant protective effect on oxidative DNA damage.

Oksidatif DNA Hasarına Karşı Punica granatum’un Koruyucu Etkisi

Oksidatif stres lipid, protein ve DNA’ya zarar verebilir. Bundan dolayı antioksidant özellik gösteren organik kaynakların, oksidatif stres sonucu oluşan hasarları önleme özelliklerinin, ortaya çıkartılması oldukça dikkat çekmiştir. Yüksek fenolik bileşik içeren yiyeceklerin birçok hastalık riskini azalttığı ve bazı kanser türlerine karşı koruyucu etkilerinin olduğu literatürde yer almıştır. Nar olarak bilinen Punica granatum L. Punicacea familyasına aittir. Oldukça önemli ve eskiden beri tüketilen bir meyve olan nar başlıca Akdeniz ülkelerinde üretilmektedir. Bu çalışmada ilk defa Derik nar suyu ve kabuğunun fenolik içeriği ve bunların fenton sistemi ile oluşturulan oksidatif DNA hasarına karşı koruma etkisi incelendi. Sonuç olarak, nar suyu ve kabuğunun DNA’da meydana gelen hasara karşı koruyucu etki gösterdiği belirlendi.

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