Halil ŞENOL, Harika Öykü DİNÇ, Beyza Nur TAK

Bazı Yeni 1,2,3-Triazol-arilidenhidrazid Hibrit Bileşiklerinin Sentezi ve Anti-mikrobiyal Etkinliklerinin Belirlenmesi

Günümüzde kansere ve diğer mikroorganizmalara karşı kullanılan ilaçların pek çoğunun biyoyararlanımının düşük olması ve başta toksisite gibi yan etkilerinden dolayı tedavide yeni ilaçların varlığına ihtiyaç duyulmaktadır. Her gün artan sayıda anti-kanser veya antibiyotik ilaç geliştirilmesine rağmen, bu ilaçların seçiciliklerinin düşük olması ve çoklu ilaç direncinin kazanılması, başarılı bir tedavinin önüne geçmektedir. Bu nedenle, tümör hücrelerini veya mikroorganizmaları yok etmek veya en azından çoğalmasını durdurmak için yeni, güçlü ve seçici ajanlarının keşfine önemli ölçüde ihtiyaç duyulmaktadır. Bu çalışma kapsamında 18 adet yeni 1,2,3-triazol/arilidenhidrazid yapısında hibrit bileşik sentezlendi. Elde edilen 18 yeni bileşiğin (17a-r) Staphylococcus Aureus ve Escheric1hia coli bakteri türleri ve Candida albicans mantar türü üzerindeki anti-mikrobiyal etkinlikleri araştırıldı. Elde edilen sonuçlar anti-mikrobiyal ilaç seftazidim ile karşılaştırıldı. Bileşiklerin anti fungal etkinliklerinin MİK değerleri 62.5 μM olarak bulunurken anti-bakteriyel etkinliklerinin MİK değerleri 62.5-125 μM olarak belirlendi.

Anahtar Kelimeler:

1, 2, 3-triazol, Hibrit bileşik, Arilidenhidrazid, Anti-mikrobiyal, Organik sentez

Synthesis of Some New 1,2,3-Triazole-Arylidenehydrazide Hybrid Compounds and Determination of Their Antimicrobial Activities

At the present time, due to the low bioavailability of many of the drugs used against cancer and other microorganisms and their side effects such as toxicity, there is a need for new drugs in the treatment. Although an increasing number of anticancer or antibiotic drugs are being developed every day, the low selectivity of these drugs and the acquisition of multidrug resistance prevent successful treatment. Therefore, there is a great need for the discovery of new, potent and selective agents to destroy or at least stop the proliferation of tumor cells or microorganisms. In this study, 18 new 1,2,3-triazole/arylidenehydrazide hybrid compounds were synthesized. Anti-microbial activities of these compounds (17a-r) were investigated on Staphylococcus Aureus and Escherichia coli and Candida albicans. The results were compared with the anti-microbial drug ceftazidime. The MIC values of the anti-fungal activities of the compounds were found as 62.5 μM, while the MIC values of the anti-bacterial activities were determined as 62.5-125 μM.

Keywords:

1, 2, 3-triazole, Hybrid Compound, Arylidenehydrazide, Anti-microbial, Organic synthesis,

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