Mustafa SERTÇELİK, Füreya Elif ÖZBEK, Serkan SUGEÇTİ, Hacali NECEFOĞLU

4-Formilbenzoat’ın Co(II), Cu(II) ve Zn(II) ile İzonikotinamid Komplekslerinin Sentezi; Spektroskopik, Termik Özelliklerinin ve Antibakteriyel Etkinliklerinin İncelenmesi

Bu çalışmada Co(II), Cu(II) ve Zn(II) metallerinin 4-formilbenzoik asit ve izonikotinamid ile üç adet kompleksi sentezlendi: Co(C6H6N2O)2(H2O)4](C8H5O3)2·2H2O, Cu2(C8H5O3)4(C6H6N2O)4, Zn(C8H5O3)2 (C6H6N2O), sentezlenen üç kompleksin yapısı elementel analiz, FT-IR spektroskopisi ve termik analiz ile sonucunda karakterize edildi. Yapıları karakterize edilen komplekslerin Esherishia coli (E. coli) ve Staphylococcus aureus (S. aureus) bakteri türleri üzerinde antibakteriyel özellikleri incelenmiştir.B3 vitamini olarak bilinen nikotinamid’in izomerlerinden biri olan izonikotinamid, γ pozisyonunda amid grubu (-CONH2 ) içeren bir piridin türevidir ve antitüberküloz, ateş düşürücü, fibrinolitik ve antibakteriyel özellikler gösterir (Ahuja and Prasad, 1976; Aguiar ve ark.., 2015). Piridin ve türevlerini içeren kompleksler gösterdikleri biyolojik aktiviteleri sayesinde biyolojik olarak önemli rol oynamaktadır (Kismali ve ark al., 2012). Biyolojik olarak önemli olan bu ligandların metal komplekslerinin bazen serbest ligandlara göre daha etkili olduğu bilinir (Ahuja and Prasad, 1976; Al-Saif and Moamen S. Refat, 2012; Surendra Dilip ve ark, 2016; Altun and Şuözer, 2017). Metal komplekslerinin Esherishia coli, Pseudomonas aeruginosa, Staphylococcus pyogones ve Candida Albicans’a karşı antibakteriyel aktivitelerinin araştırıldığı bir çalışmada

Anahtar Kelimeler:

Geçiş Metalleri, 4-Formilbenzoik Asit, İzonikotinamid, Antibakteriyel, Antibakteriyel

Synthesis Of Izonicotınamide Complexes Of 4-Formilbenzoate with Co (II), Cu (II) And Zn (II); Investigation of Spectroscopic, Thermal Properties and Antibacterial Activıties

In this work, three complexes of Co (II), Cu (II) and Zn (II) metals with 4-formylbenzoic acid and isonicotinamide were synthesized: Co(C6H6N2O)2(H2O)4](C8H5O3)2·2H2O, Cu2(C8H5O3)4(C6H6N2O)4, Zn(C8H5O3)2 (C6H6N2O), the structure of the three complexes synthesized was characterized as the result of elemental analysis, FT-IR spectroscopy and thermal analysis. The antibacterial properties of the constricted complexes on Esherishia coli (E. coli) and Staphylococcus aureus (S. aureus) bacterial species were investigated.

Keywords:

Transition Metals, 4-Formylbenzoic Acid, Isonicotinamide, Antibacterial,

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