Havva Hande KESER ŞAHİN, Orhan ASLAN, Yılmaz BAŞ

Tiroid Kanserlerinde Histomorfolojik Bulguların Değerlendirilmesi ve Diyabet ile Birlikteliği

Amaç: Bu çalışmada tiroid kanseri türleri ile diabetes mellitus arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: 2016-2018 yılları arasında Hitit Üniversitesi Erol Olçok Eğitim ve Araştırma Hastanesi Patoloji bölümünde tanı alan 406 tiroidektomi olgusu retrospektif olarak hastane bilgisayar kayıt sisteminden ve Patoloji kliniği arşivinden tarandı. Bu vakalar içerisinden tiroid kanseri tanısı alanlar belirlendi. Tiroid kanserli olgulardan Diyabetes Mellitus tanılı olanlar hastane bilgi sisteminden tespit edildi. Olgular tanılarına, cinsiyet, yaş, tümör tipi, tümör lokalizasyonu, tümör çapı, lenf nodu metastazı ve uzak organ metastazı açısından sınıflandırıldı. İmmünohistokimyasal HBME1, Galaktin 3 ve Sitokeratin-19 ekspresyonu incelendi. Bulgular: Tiroid karsinomu tanısı alan 109 olgu vardı. Bu olguların yaş ortalaması 51,1’di. Kadın/erkek oranı 2,9’du. Kanser olguları 4. dekatta en yüksek oranda görülmekteydi. Tiroid papiller karsinom 55 (%50,5), mikrokarsinom 48 (%44,0), folliküler karsinom 3 (%2,8) ve medüller karsinom tanısı alan 3 (%2,8) olgu vardı. Olguların 12’inde (%11,0) vasküler invazyon ve kapsül invazyonu vardı. Tiroid papiller karsinom tanısı alan 2 (%1,8) olguda lenf nodu metastazı vardı. Tiroid kanserli 109 hastanın 14’ünde (%12,8) diyabetes mellitus vardı. Çalışma grubumuzdaki hastaların diyabet oranı ile genel popülasyon diyabet oranı karşılaştırıldığında istatistiksel olarak anlamlı farklılık saptanmamıştır (p=0,519). Sonuç: Çalışmamızda diyabetin tiroid kanseri için bir risk faktörü olmadığı görülmüştür. Diyabetin düşük orandaki birlikteliği nedeniyle, diyabetli hastalarda tiroid bezi kontrolünün yapılmasının gerekliliği ortaya çıkmıştır. Diyabetin tiroid kanseri için bir risk faktörü olduğunu belirtmek için daha çok veriye ihtiyaç vardır.

Anahtar Kelimeler:

tiroid, kanser, diyabet

Evaluation of Histomorphological Findings in Thyroid Cancers and Association with Diabetes

Objective: This study aimed to investigate the relationship between thyroid cancer types and Diabetes Mellitus (DM). Material and Methods: Between 2016-2018, 406 thyroidectomy cases diagnosed in the Pathology department of Hitit University Erol Olçok Training and Research Hospital were retrospectively reviewed from the hospital computer registration system and the archive of the Pathology clinic. Among these cases, patients diagnosed with thyroid cancer were identified. Among the thyroid cancer cases, those diagnosed with DM were identified using hospital records. Cases were classified based on diagnosis, gender, age, tumor type, tumor localization, tumor diameter, lymph node metastasis, and distant organ metastasis. HBME1, Galactin 3, and Cytokeratin-19 expression were analyzed immunohistochemically. Results: There were 109 patients diagnosed with thyroid carcinoma. The mean age of these patients was 51.1 years, and the male/female ratio was 2.9. Cancer cases were most common in the fourth decade. There were 55 (50.5%) cases of thyroid papillary carcinoma, 48 (44.0%) cases of microcarcinoma, 3 (2.8%) cases of follicular carcinoma and 3 (2.8%) cases of medullary carcinoma. Vascular invasion and capsular invasion were observed in 12 cases (11.0%). Lymph node metastasis was present in 2 (1.8%) patients diagnosed with thyroid papillary carcinoma. DM was present in 14 (12.8%) of 109 patients with thyroid cancer. When the DM rate of the patients in our study group was compared with the DM rate in the general population, no statistically significant difference was found (p=0.519). Conclusion: In our study, DM was not found to be a risk factor for thyroid cancer. Due to the low association rate of DM, it is necessary to check the thyroid gland in patients with diabetes mellitus. More data and further studies are needed to indicate that diabetes is a risk factor for thyroid cancer.

Keywords:

Thyroid, cancer, diabetes,

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