Göz Kuruluğu Şikayetiyle Başvuran Sjögren Sendromlu Hastalarda Anti-HCV Seroprevalansının Araştırılması

Amaç: Sjögren Sendromu (SS) esas olarak ekzokrin bezleri tutan ve tükrük ve gözyaşı bezlerinin tutulumu sonucu ağız ve gözlerin kuruluğu ile karakterize sistemik otoimmün bir hastalıktır. Hepatit C virüs (HCV) enfeksiyonu ile SS/sicca sendromu arasında anlamlı bir ilişki vardır. HCV hem SS’nun etyolojisinde suçlanmış hem de sicca sendromu HCV enfeksiyonunun karaciğer dışı belirtilerinden biri olarak gösterilmiştir. Bu çalışmada, Göz Hastalıkları kliniğine başvuran ve SS tanısı alan hastalarda Anti-HCV seroprevalansının araştırılması amaçlanmıştır. Veriler hastane otomasyon sisteminden retrospektif olarak elde edilmiştir. Bulgular: Şubat 2017 ile Şubat 2023 tarihleri arasındaki göz polikliniğine başvuran ve sjögren sendromu tanısı ile siklosporin reçetelenen toplam 2281 hasta verisi elde edildi. Otomasyon sisteminden bu hastaların 521 tanesinin anti-HCV testi yapıldığı saptandı. Yedi hastada (%1,3) anti-HCV testi pozitif bulundu. Anti-HCV testi pozitif olanların olmayanlara göre yaş ortalamaları anlamlı oranda yüksek bulunurken cinsiyetler arasında fark bulunmadı. Sonuç: Bu çalışmada kuru göz semptomu olan hastalarda anti-HCV pozitifliği genel populasyonla benzer bulunmuştur. Kuru göz semptomu olan tüm hastaların SS açısından değerlendirilmesi ve HCV enfeksiyonu ile birlikteliği akılda tutularak anti-HCV testlerinin yapılması daha sağlıklı veriler elde edilmesi açısından önemlidir.

Anahtar Kelimeler:

Sjögren Sendromu, kuru göz, sicca sendromu, Anti-HCV seroprevalansı

Investigation of Anti-HCV Seroprevalence In Patients With Sjögren's Syndrome Presenting With The Comlaint of Dry Eye

Objective: Sjögren's Syndrome (SS) is a systemic autoimmune disease that mainly involves the exocrine glands and is characterized by dry mouth and eyes as a result of involvement of the salivary and lacrimal glands. There is a significant relationship between hepatitis C virus (HCV) infection and SS/sicca syndrome. HCV has been implicated in the etiology of SS and sicca syndrome has been shown as one of the extrahepatic manifestations of HCV infection. In this study, it was aimed to investigate the anti-HCV seroprevalence in patients who applied to the Ophthalmology clinic and were diagnosed with SS. The data were obtained retrospectively from the hospital automation system. It was determined from the automation system that 521 of these patients were tested for anti-HCV. Anti-HCV test was positive in seven patients (1.3%). While the mean age of those with positive anti-HCV test was found to be significantly higher than those who did not, there was no difference between genders. Conclusion: In this study, anti-HCV positivity was found to be similar to the general population in patients with dry eye symptoms. Results: Data of 2281 patients who applied to the eye outpatient clinic between February 2017 and February 2023 and were prescribed cyclosporine with the diagnosis of Sjögren's syndrome were obtained. It is important to evaluate all patients with dry eye symptoms in terms of SS and to perform anti-HCV tests, keeping in mind its association with HCV infection, in order to obtain more reliable data.

Keywords:

Sjögren Sendromu, kuru göz, sicca sendromu, Anti-HCV seroprevalansı,

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